Parameters | With persistent hematuria in remission (n = 80) | Without hematuria in remission (n = 64)a | P value |
---|---|---|---|
Baseline data | |||
Sex (male/female) | 31/49 | 27/37 | 0.68 |
Age (years) | 57.2 ± 12.3 | 58.8 ± 14.5 | 0.50 |
Hypertension (n %) | 20/25.0 | 23/35.9 | 0.15 |
Cardiovascular disease (n %) | 11/13.8 | 8/12.5 | 0.83 |
Diabetes (n %) | 10/12.5 | 13/20.3 | 0.20 |
Using ACEI/ARB (n %) | 18/22.5 | 11/17.2 | 0.43 |
ANCA subtypes (PR3/MPO) | 11/69 | 4/60 | 0.14 |
ANCA level (RU/mL) | 187.0(96.0,200.0) | 142.0(88.0,200.0) | 0.14 |
BVAS | 19.1 ± 6.9 | 19.0 ± 7.0 | 0.96 |
Hemoglobin (g/L) | 97.5 ± 21.2 | 98.7 ± 19.6 | 0.76 |
Leukocyte (×109/L) | 8.5 ± 2.9 | 9.2 ± 2.7 | 0.19 |
Neutrophil (×109/L) | 6.4 ± 2.9 | 6.8 ± 2.5 | 0.41 |
Platelets (×109/L) | 259.4 ± 102.3 | 271.8 ± 108.0 | 0.53 |
ESR (mm/1 h) | 56.5(43.5,79.8) | 85.0(45.5,110.0) | 0.009 |
C-reactive protein (mg/L) | 9.8(3.5,39.2) | 18.4(8.7,62.6) | 0.043 |
Urine protein excretion (g/24 h) | 1.0(0.3,1.8) | 0.9(0.6,1.7) | 0.62 |
Serum creatinine (μmol/L) | 167.5 (111.5,341.0) | 163.0(110.1,329.8) | 0.10 |
eGFR (mL/min/1.73m2) | 39.2 ± 28.9 | 39.2 ± 29.1 | 0.10 |
Fever (n/%) | 31/38.8 | 23/35.9 | 0.73 |
Fatigue (n/%) | 36/45.0 | 34/53.1 | 0.33 |
Rash (n/%) | 10/12.5 | 9/14.1 | 0.64 |
Weight loss (n/%) | 31/38.8 | 33/51.6 | 0.12 |
Muscle pain (n/%) | 13/16.3 | 15/23.4 | 0.28 |
Arthralgia (n/%) | 15/18.8 | 9/14.1 | 0.78 |
Lung (n/%) | 49/61.3 | 35/54.7 | 0.47 |
ENT (n/%) | 37/46.3 | 29/45.3 | 0.91 |
Gastrointestinal tract (n/%) | 23/28.8 | 15/23.4 | 0.47 |
Nervous system (n/%) | 7/8.8 | 11/17.2 | 0.13 |
Prednisone-equivalent dose (g) | 8.9 ± 4.0 | 9.7 ± 3.2 | 0.23 |
Oral CTX/IV CTX | 8/72 | 7/57 | 0.65 |
Data at the beginning of maintenance therapy | |||
Serum creatinine (μmol/L) | 115.5(96.5,145.0) | 122.0(95.3,160.3) | 0.43 |
eGFR (mL/min/1.73m2) | 54.1 ± 21.16 | 51.1 ± 22.5 | 0.42 |
ANCA level (RU/mL) | 42.5(0.0,81.8) | 0.0(0.0,37.4) | 0.003 |
ESR (mm/1 h) | 20.0(11.0,33.0) | 19.0(15.0,34.0) | 0.51 |
C-reactive protein (mg/L) | 3.0(1.0,8.0) | 3.0(1.0,5.8) | 0.52 |
Proteinuria (n/%)b | 48(61.5%) | 22(34.4%) | 0.001 |
IV CTX every 3 mo/AZA/MMF | 25/53/2 | 17/42/5 | 0.45 |
The slope of eGFR decline (mL/min/1.73 m2/y) | 3.6(1.2,7.2) | 0.2(−0.2,0.8) | <0.001 |