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Table 4 Cytokines trend in the two different groups of patients

From: The effect of whole-body cooling on renal function in post-cardiac arrest patients

 

Entire Cohort n = 36

AKI n = 15

No AKI n = 21

p

OR

95% CI

IL-6

 Admission

79.05 [31.34–113.52]

82.79 [37.12–93.31]

62.32 [28.66–139.95]

0.28

0.99

0.98–1.00

 6 h

56.9 [22.52–165.45]

36.50 [12.1–60.18]

64.96 [22.52–188.4]

0.62

0.99

0.99–1.00

 12 h

53.58 [39.04–121.25]

45.17 [28.91–53.76]

63.88 [47.79–177.5]

0.38

0.99

0.99–1.00

 24 h

46.75 [22.36–94.37]

46.46 [21.21–64.29]

46.75 [22.69–98.61]

0.80

0.99

0.98–1.00

 48 h

44.38 [26.45–78.45]

57.83 [31.93–74.84]

40.63 [24.33–82.06]

0.69

1.00

0.99–1.01

 72 h

48.89 [27.85–73.38]

43.47 [27.77–89.84]

48.91 [27.93–67.1]

0.24

1.00

0.99–1.02

IL-1beta

 Admission

13.27 [11.3–20.41]

11.87 [10.87–15.2]

14.91 [12.3–23.22]

0.28

0.96

0.90–1.03

 6 h

13.04 [9.93–16.48]

10.76 [9.58–13.98]

14.65 [11.52–20.43]

0.29

0.97

0.91–1.03

 12 h

13.13 [11.71–16.54]

12.94 [10.52–20.33]

13.13 [12.34–14.92]

0.74

1.01

0.94–1.08

 24 h

14.15 [11.85–21.92]

14.14 [11.43–18.76]

14.79 [11.96–21.92]

0.54

0.98

0.93–1.04

 48 h

13.58 [11.62–17.52]

15.93 [11.21–19.01]

13.55 [11.62–16.63]

0.73

0.99

0.93–1.05

 72 h

14.21 [11.64–22.27]

14.20 [10.56–17.22]

14.31 [11.64–49.43]

0.51

0.98

0.94–1.03

uIL-18

 Admission

370.13 [319.63–740.5]

559.35 [369.76–997.36]

361.64 [309.94–412.06]

0.29

1.00

0.99–1.00

 12 h

325.7 [299.6–375.5]

317.97 [262.60–345.89]

329.16 [303.16–375.9]

0.50

0.99

0.99–1.00

 24 h

330.16 [280.93–365.5]

327.42 [288.01–361.53]

330.16 [219.25–373]

0.91

0.99

0.99–1.00

 48 h

335.92 [289.68–393.47]

355.5 [301.5–566.52]

331.24 [277.84–365.5]

0.29

1.00

0.99–1.00

 72 h

331.96 [207–439.37]

366.61 [331.92–845.5]

323.71 [130.05–405.5]

0.16

1.00

0.99–1.00

  1. All cytokines concentrations are expressed in pg/ml and presented as median value [IQR]. The difference in cytokines concentrations at each time points has been tested again the AKI development through multivariate analysis
  2. Abbreviations: IL-6 Interleukin 6, IL-1beta Interleukin 1beta, uIL-18 urinary Interleukin 18, AKI, Acute Kidney Injury