Table 1 Clinicopathologic characteristics of IgAN patients of different genders
Variable | Total (n = 988) | Males (n = 417) | Females (n = 571) | P-value |
|---|---|---|---|---|
Age (years) | 32 (26, 39) | 31 (24, 38) | 32 (27, 39) | 0.003 |
Systolic blood pressure (mmHg) | 123 (112, 136) | 128 (119, 140) | 119 (110, 133) | < 0.001 |
Diastolic blood pressure (mmHg) | 79 (70, 88) | 80 (71, 89) | 78 (70, 87) | < 0.001 |
Hypertension (n [%]) | 331 (33.5) | 168 (40.3) | 163 (28.5) | < 0.001 |
Proteinuria (g/d) | 0.58 (0.30, 1.21) | 0.69 (0.33, 1.47) | 0.53 (0.27, 1.05) | < 0.001 |
Microscopic haematuria (n [%]) | 0.006 | |||
<++ | 590 (60.0) | 271 (65.1) | 319 (56.3) | |
≥++ | 393 (40.0) | 145 (34.9) | 248 (43.7) | |
Gross haematuria (n [%]) | 280 (28.3) | 82 (19.7) | 198 (34.7) | < 0.001 |
Haemoglobin (g/L) | 127.0 (115.0, 140.0) | 139.0 (128.0, 151.0) | 121.0 (111.0, 129.0) | < 0.001 |
Total protein (g/L) | 67.0 (61.0, 71.0) | 67.0 (62.0, 72.0) | 66.0 (61.0, 71.0) | 0.613 |
Albumin (g/L) | 40.0 (36.5, 42.9) | 41.0 (37.4, 43.0) | 39.0 (36.0, 42.0) | < 0.001 |
Cholesterol (mmol/L) | 4.97 (4.2, 5.9) | 4.9 (4.2, 5.9) | 5.0 (4.3, 5.9) | 0.932 |
Hypercholesterolaemia (n [%]) | 397 (42.0) | 168 (41.7) | 229 (42.3) | 0.894 |
Triglycerides (mmol/L) | 1.25 (0.87, 1.90) | 1.39 (0.98, 2.00) | 1.15 (0.77, 1.81) | < 0.001 |
Hypertriglyceridaemia (n [%]) | 282 (29.8) | 136 (33.7) | 146 (26.9) | 0.026 |
SUA (μmol/L) | 348 (269, 429) | 405 (343, 492) | 295 (239, 373) | < 0.001 |
Hyperuricaemia (n [%]) | 322 (34.7) | 174 (43.9) | 148 (27.9) | < 0.001 |
Scr (mmol/L) | 80.0 (61.0, 116.5) | 102.0 (81.0, 161) | 64.0 (55.0, 89.0) | < 0.001 |
BUN (mmol/L) | 5.4 (4.4, 7.2) | 6.2 (4.8, 8.1) | 4.9 (4.1, 6.3) | < 0.001 |
eGFR (mL/min/1.73 m2) | 95.5 (59.9, 123.2) | 80.8 (42.9.1, 107.4) | 111.3 (71.9, 133.7) | < 0.001 |
Mean proportion of global glomerulosclerosis (%) | 11.1 (0.0, 30.8) | 13.3 (0.0, 35.7) | 10.0 (0.0, 27.8) | 0.205 |
Crescent (n [%]) | 434 (43.9) | 195 (46.8) | 239 (41.9) | 0.136 |
Mesangial hypercellularity (M1) (n [%]) | 524 (54.0) | 225 (55.3) | 299 (53.1) | 0.514 |
Endocapillary hypercellularity (E1) (n [%]) | 193 (20.4) | 77 (19.4) | 116 (21.1) | 0.568 |
Segmental sclerosis (S1) (n [%]) | 447 (46.3) | 204 (50.4) | 243 (43.3) | 0.031 |
Tubular atrophy/interstitial fibrosis (T) (n [%]) | 0.001 | |||
T0 | 711 (73.5) | 273 (67.4) | 438 (77.9) | |
T1 | 227 (23.5) | 119 (29.4) | 108 (19.2) | |
T2 | 29 (3.0) | 13 (3.2) | 16 (2.8) | |
Interstitial inflammation (n [%]) | 0.020 | |||
None~mild | 818 (82.8) | 329 (78.9) | 489 (85.6) | |
Moderate | 151 (15.3) | 79 (18.9) | 72 (12.6) | |
Severe | 19 (1.9) | 9 (2.2) | 10 (1.8) | |
ACEi/ARB (n [%]) | 781 (79.4) | 335 (80.9) | 446 (78.2) | 0.338 |
Corticosteroids (n [%]) | 293 (29.8) | 137 (33.1) | 156 (27.4) | 0.057 |
Immunosuppressive agents (n [%]) | 22 (2.3) | 11 (2.7) | 11 (2.0) | 0.515 |
Allopurinol (n [%]) | 54 (5.5) | 44 (10.7) | 10 (1.8) | <0.001 |