Table 2 Baseline characteristics of patients according to disease severity groups
| Â | Disease severity | p-value | |
|---|---|---|---|
Low severity (SOFA < 12) | High severity (SOFA ≥12) | ||
Number | 601 | 543 | Â |
BMI (kg/m2)a | 23.4 (20.8–25.9) | 23.9 (21.2–26.7) | 0.009 |
Age (yr) | 64.9 ± 14.8 | 61.3 ± 13.8 | <  0.001 |
Sex (Female, %) | 250 (41.6) | 189 (34.8) | 0.02 |
DM (n, %) | 247 (41.2) | 152 (28.0) | <  0.001 |
HTN (n, %) | 377 (62.7) | 224 (41.3) | <  0.001 |
MI (n, %) | 82 (13.6) | 30 (5.5) | <  0.001 |
CHF (n, %) | 136 (22.6) | 50 (9.2) | <  0.001 |
CVA (n, %) | 75 (12.4) | 43 (8.0) | 0.04 |
PVD (n, %) | 32 (5.3) | 14 (2.6) | 0.02 |
COPD (n, %) | 49 (8.2) | 31 (5.7) | 0.13 |
Cancer (n, %) | |||
 Solid tumor | 99 (16.6) | 160 (29.5) |  |
 Metastasis | 28 (4.7) | 40 (7.4) | <  0.001 |
 Leukemia | 15 (2.5) | 36 (6.6) |  |
 Lymphoma | 65 (10.9) | 43 (7.9) |  |
CCI score | 3.0 ± 2.3 | 3.4 ± 2.2 | 0.002 |
Sepsis (n, %) | 439 (73.0) | 358 (65.9) | 0.01 |
Postop AKI (n, %) | 23 (3.8) | 28 (5.2) | 0.32 |
Cause of CRRT | |||
 Volume overload | 94 (15.6) | 50 (9.3) |  |
 Metabolic acidosis | 126 (21.0) | 118 (21.7) |  |
 Hyperkalemia | 35 (5.8) | 17 (3.1) | 0.05 |
 Uremia | 50 (8.4) | 80 (14.7) |  |
 Oliguria | 165 (27.4) | 118 (21.7) |  |
 Others | 131 (21.9) | 160 (29.5) |  |
CRRT dose (mL/kg) | 39.6 ± 12.9 | 45.1 ± 18.3 | <  0.001 |
MAP (mmHg) | 78.4 ± 15.0 | 76.4 ± 14.1 | 0.03 |
Creatinine (mg/dL) | 2.6 ± 1.6 | 2.9 ± 1.6 | 0.001 |
eGFR (mL/min/1.73m2) | 33.6 ± 23.7 | 29.4 ± 18.4 | 0.001 |
Albumin (g/dL) | 2.6 ± 0.6 | 2.6 ± 0.6 | 0.23 |
Total cholesterol (mg/dL) | 111.9 ± 53.3 | 98.7 ± 61.4 | 0.002 |
WBC (×103/mm3) | 14.7 ± 14.0 | 13.4 ± 12.1 | 0.08 |
Hemoglobin (g/dL) | 9.7 ± 2.4 | 9.5 ± 2.2 | 0.04 |
CRP (mg/L)a | 64.8 (13.6–156.6) | 75.2 (17.5–170.9) | 0.12 |
Vasopressor (n, %) | 380 (63.3) | 419 (77.1) | <  0.001 |
Ventilator (n, %) | 418 (77.1) | 366 (93.8) | <  0.001 |
SOFA | 9.4 ± 2.3 | 15.1 ± 1.9 | <  0.001 |
APACHE II | 24.6 ± 8.8 | 29.7 ± 7.1 | <  0.001 |