The impact of disease severity on paradoxical association between body mass index and mortality in patients with acute kidney injury undergoing continuous renal replacement therapy

Table 4 Multivariable Cox regression analyses for 30-day mortality

Disease severity	BMI classification	Model 1		Model 2		Model 3		Model 4
Disease severity	BMI classification	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value
Low	Underweight	1.57 (1.07–2.30)	0.02	1.66 (1.13–2.45)	0.01	1.74 (1.16–2.60)	0.007	0.99 (0.96–1.01)	0.36
	Normal	1.00 (Reference)		1.00 (Reference)		1.00 (Reference)
	Overweight	1.44 (1.05–1.99)	0.03	1.48 (1.07–2.04)	0.02	1.41 (1.02–1.94)	0.04
	Obesity	1.31 (0.98–1.76)	0.07	1.35 (1.01–1.82)	0.04	1.28 (0.95–1.72)	0.11
High	Underweight	1.07 (0.73–1.56)	0.74	1.03 (0.70–1.51)	0.9	1.04 (0.70–1.53)	0.86	0.96 (0.94–0.98)	< 0.001
	Normal	1.00 (Reference)		1.00 (Reference)		1.00 (Reference)
	Overweight	0.79 (0.60–1.05)	0.11	0.81 (0.61–1.07)	0.14	0.78 (0.58–1.03)	0.08
	Obesity	0.63 (0.50–0.79)	< 0.001	0.64 (0.51–0.80)	< 0.001	0.61 (0.48–0.76)	< 0.001
Total	Underweight	1.27 (0.97–1.66)	0.08	1.27 (0.97–1.67)	0.08	1.28 (0.97–1.68)	0.08	0.97 (0.96–0.99)	< 0.001
	Normal	1.00 (Reference)		1.00 (Reference)		1.00 (Reference)
	Overweight	1.02 (0.83–1.26)	0.87	1.02 (0.83–1.27)	0.83	0.99 (0.80–1.22)	0.89
	Obesity	0.84 (0.70–1.01)	0.06	0.86 (0.72–1.03)	0.1	0.81 (0.68–0.97)	0.03

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