BMC Nephrology

Table 3 Urinary concentrations of Tryptophan and respective metabolites

From: Increased urinary excretion of kynurenic acid is associated with non-recovery from acute kidney injury in critically ill patients

		DAY 1			DAY 2			DAY 3
		ER	LNR	p	ER	LNR	p	ER	LNR	p
Trp/cr	umol/mmol	5.51 ± 4.95	6.10 ± 6.75	NS	9.50 ± 14.91	7.28 ± 7.84	NS	12.08 ± 10.49	6.0 ± 5.6	< 0.005
Kyn/cr	umol/mmol	2.90 ± 4.87	2.94 ± 7.65	NS	3.88 ± 5.69	4.30 ± 8.80	NS	5.60 ± 8.17	2.2 ± 4.8	< 0.0001
KynA/cr	umol/mmol	3.19 ± 3.44	7.59 ± 6.81	< 0.005	1.87 ± 1.10	9.17 ± 9.67	< 0.0001	2.00 ± 1.28	6.51 ± 9.49	< 0.001
3 OH AA/cr	umol/mmol	1.36 ± 2.86	1.04 ± 1.82	NS	1.14 ± 1.62	0.72 ± 1.04	NS	2.02 ± 3.11	0.75 ± 0.99	< 0.05
Serotonine/cr	umol/mmol	0.045 ± 0.075	0.053 ± 0.11	NS	0.038 ± 0.026	0.036 ± 0.041	NS	0.045 ± 0.035	0.027 ± 0.037	< 0.005
Phenylalanine/cr	umol/mmol	5.50 ± 5.02	9.41 ± 12.84	NS	7.56 ± 11.80	9.77 ± 12.03	NS	8.49 ± 7.55	6.73 ± 6.81	NS
OH-Trp/cr	umol/mmol	0.12 ± 0.18	0.23 ± 0.72	NS	0.11 ± 0.077	0.13 ± 0.106	NS	0.11 ± 0.068	0.11 ± 0.078	NS
KynA/Trp		1.37 ± 2.86	2.30 ± 2.73	< 0.01	0.47 ± 0.66	1.8 ± 1.8	< 0.0001	0.26 ± 0.20	1.33 ± 1.25	< 0.0001
Kyn/Trp		0.66 ± 1.24	0.34 ± 0.33	NS	0.64 ± 1.08	0.58 ± 0.93	NS	0.73 ± 1.58	0.30 ± 0.41	< 0.05

3OH AA 3-hydroxy anthranilic acid, cr creatinine, d day, ER early recovery, Kyn kynurenine, KynA kynurenic acid, LNR late−/non-recovery, OH-Trp 5-hydroxy tryptophan, Trp tryptophan. Urinary concentrations of Trp and respective metabolites were normalized to urinary creatinine concentrations (except KynA/Trp ratio). Results are given as mean ± standard deviations for the first 3 days of AKI (d1, d2, and d3)

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