Fig. 2

Renal injury in WT (white bars) and NOD1/2 DKO (black bars) mice after 0, 3, 7, and 14 days following obstruction. Renal damage was evaluated by blinded scoring of the necrotic tubules in PAS-D-stained sections (a, c) and by measuring the mRNA expression of KIM-1 (b) in total kidney homogenates. Data are expressed as mean ± SEM. Results were analysed with the non-parametric two-tailed Mann-Whitney U-test. *P < 0.05. N = 9/group