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Table 3 Clinical and laboratory data before and after PTX

From: Full normalization of severe hypertension after parathryoidectomy – a case report and systematic review

Ref

Author, year

N cases

Age (years)

PTH pre/post (pg/ml)

BP pre/post (mmHg)

Other

Antihypertensive treatment

6

Lin, 2013

30*

53.3 ± 13.3

1012 ± 247 vs 136 ± 157 (P <  0.001)

Sys:148 ± 17 vs 139 ± 18

Dia: 79 ± 10 vs 74 ± 12

(P <  0.009; < 0.007)

Ca, PO4, Ca x Ph, hemoglobin improved after PTX;

No data

7

Shih, 2013

21

57.4 ± 12

1011(611–1402) vs 19.1 (10.3–61.6)

6 mos (P < 0.001)

Sys:138.9 ± 16.4 vs 121.2 ± 18.6

Dia: 77.6 ± 8.3 vs 69.2 ± 9.8 (P < 0.001)

Improved heart function; reduced intradialytic hypotension.

Pre PTX: 1.14 ± 1.11 drugs

Post PTX: 0.67 ± 1.2 drugs

8

Leiba, 2013

3

45, 46, 30

2408 / 6

7000 / 2000

3642 / 16–30

Sys: 140; 180–200;

175–210 vs 60; 50; 100

Dia: 90; 100; 120 vs 40; 30; 60

 

Pre PTX Case 1: no data

Case 2: clonidine, amlodipine, atenolol

doxazosin

Case 3: clonidine, minoxidil

9

De Santo, 2010

40

55.8 ± 6.8

1.299.6 / 46.8

Sys: 139 vs 135

Dia: 83 vs 81

(P < 0.001, P = 0.001)

 

treated

Pre PTX 100%

Post PTX 72.5%

10

Esposito, 2008

16

54.6 ± 13

1434 ± 400 vs 40.3 ± 37.4

Sys: 138.9 ± 18.39 vs 130.8 ± 23.47 (P = 0.05)

Dia: 83.1 ± 11.84 vs 78.8 ± 6.7 (P = 0.05)

Beneficial effects of PTX on sleep disorders.

Pre PTX, all on combined treatment**

Post PTX: 12 /16 on antihypertensive drugs.

11

Chow, 2003

12

50 ± 11

243.6 ± 22.6 vs 9.2 ± 13.4

Sys: 141 ± 16 vs 145 ± 16

Dia: 77 ± 10 vs 80 ± 10

P = NS

No effect on pruritus; regression of left ventricular hypertrophy

Pre PTX: ACEi: 2 (17%);

Post PTX: ACEi 1 (8%) P = NS

12

Almirall, 2002

17

NS

1056 ± 803 (pre-PTX)

Sys: 140.5 ± 17.3 vs 141 ± 20.8

Dia: 81.6 ± 9.3 vs 80.4 ± 9.3 P = NS

No effect on heart rate, dry body weight

No difference after PTX

13

Saatci, 2002

13

41.38 ± 10.85

1210.25 ± 262.2 vs 172.88 ± 155.88

Sys: 126 ± 25.9 vs 102.8 ± 20.5 (P < 0.01)

Dia: 74 ± 16.46 vs 64.44 ± 15.89 (P < 0.04)

Decline in BP, if PTH < 200 ng/l.

Benefits to triglyceride levels

Groups similar at baseline

14

Coen G, 2001

45

56 ± 11

1313.4 ± 1.004.1 vs 214.2 ± 357.4 (1 week-6 months)

Sys: 134.7 ± 29.2 vs 125.9 ± 25.8

Dia: 81.6 ± 14.6 vs 77.8 ± 12.9 (P < 0.001)

No difference between subtotal or total PTX; increased erythropoietin level

Anti-hypertensive number and doses reduced post PTX

  1. * 23 controls; ** combined treatment: (betablockers, calcium channel blockers, ACEi, ARB receptors antagonists); BP = blood pressure; sys = systolic blood pressure; dia = diastolic blood pressure; PTX = parathyroidectomy