Fig. 1

a-d Kidney biopsy 2 months post TX with mild intracapillary proliferation (arrow, a) and intense mesangiocapillary C3-deposit (b). In EM mesangial and intramembranous osmiophilic deposits are seen (arrows, c). Additionally, moderate tubulitis was present indicative of acute cellular rejection Banff IA (d). e-h Kidney biopsy 2,5 months post TX with persistent C3-dominant GN (e, f) signs of hematuria with erythrocyte cylinders (arrow, g) and only mild persistent tubulitis diagnostic of borderline cellular rejection (arrows, h). i-l Kidney biopsy 5 months after TX showing intracapillary proliferative GN (a) with persistently intense C3-deposits (j) and osmiophilic deposits in the lamina densa of the glomerular basement membrane and the mesangia (k). Additionally signs of hematuria (arrow, l). All LM pictures were taken with an AxioCam MRc and an Imager. A1 Axio microscope (Zeiss, Germany). a, b, d, e, f, h, i, j at 400× original magnification (o.m.), g, l 200× o.m. EM pictures (c, k) taken at a 5000× o.m. with a Leo912 electron microscope (Zeiss, Germany)