Table 2 Subgroup analyses of overall graft failure associated with HLA per mismatch and HLA-DR mismatches

Sample size

0.835

0.011

 ≥10,000

281,141 (5)

1.06 (1.05–1.07)

49.1

145,351 (2)

1.07 (1.04–1.10)

0

 < 10,000

8614 (7)

1.06 (1.03–1.09)

17.3

4652 (5)

1.27 (1.12–1.43)

48.4

Nature of data

0.133

0.076

 Univariable-unadjusted

1440 (4)

1.14 (1.04–1.26)

24.8

2598 (2)

1.39 (1.05–1.83)

70.0

 Multivariable-adjusted

286,755 (12)

1.06 (1.05–1.07)

27.4

150,003 (7)

1.08 (1.05–1.11)

58.3

Data source

0.683

0.011

 Registry/Multi-center

286,283 (6)

1.06 (1.05–1.07)

38.9

145,351 (2)

1.07 (1.04–1.10)

0

 Single-center

3472 (6)

1.07 (1.02–1.12)

26.6

4652 (5)

1.27 (1.12–1.43)

48.4

Donor source

0.027

0.616

 Cadaveric

138,516 (5)

1.07 (1.06–1.07)

0.00

41,284 (5)

1.08 (1.04–1.11)

66.4

 Living and Cadaveric

151,239 (7)

1.05 (1.05–1.06)

16.4

108,719 (2)

1.09 (1.04–1.15)

55.4

 Geographical locations

0.053

0.033

 Europe

138,988 (6)

1.07 (1.06–1.08)

0.00

1952 (4)

1.32 (1.09–1.60)

59.7

 North America

137,880 (4)

1.05 (1.04–1.06)

2.1

145,351 (2)

1.07 (1.04–1.10)

0

 Asia

225 (1)

1.24 (1.00–1.55)

–

2700 (1)

1.23 (1.05–1.45)

–

 Oceania

12,662 (1)

1.07 (1.03–1.12)

–

0

–

–

Year period

0.175

0.026

 Prior to 1995

103,915 (6)

1.06 (1.05–1.07)

0.00

148,051 (3)

1.08 (1.04–1.12)

26.8

 Not prior to 1995

185,626(5)

1.06 (1.05–1.08)

60.1

4054 (4)

1.36 (0.98–1.88)

59.7

 NR

214 (1)

0.83 (0.51–1.34)

–

–

–

–

–

–