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Table 3 Multivariable-adjusted odds ratios of chronic kidney disease by Dichotomizeda Angiogenesis-related Factors

From: The association of angiogenic factors and chronic kidney disease

 

Age, gender, and race-adjusted

Multivariable-adjustedb

Odds ratios

95% CI

p-value

Odds ratios

95% CI

p-value

VEGF-A ≥ 160.7 pg/mL

1.84

1.17–2.90

0.01

2.40

1.20–4.81

0.01

Angiopoietin-1 ≥ 5659.5 pg/mL

0.87

0.55–1.36

0.54

1.15

0.57–2.32

0.70

Angiopoietin-1/VEGF-A ≤ 24.2

3.19

2.00–5.10

< 0.001

3.59

1.80–7.18

0.0003

VEGFR-1 ≥ 159.7 ng/mL

1.10

0.70–1.75

0.68

1.36

0.67–2.75

0.40

VEGFR-2 ≥ 28.3 ng/ml

1.28

0.81–2.01

0.29

1.11

0.55–2.22

0.78

Pentraxin-3 ≥ 1.13 ng/mL

1.86

1.18–2.94

0.008

1.74

0.86–3.52

0.13

  1. aDichotomized as upper tertile compared to lower two tertiles for all biomarkers except the ratio of angiopoietin-1/VEGF-A, which was dichotomized as lowest tertile compared to upper two tertiles
  2. bAdjusted for age, race, gender, current cigarette smoking, weekly alcohol consumption, physical activity ≥twice/week, BMI, LDL-cholesterol, HDL-cholesterol, C-reactive protein, fasting plasma glucose, systolic BP, use of aspirin or lipid-lowering, antihypertensive, or antidiabetic medications, and history of CVD
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BMC Nephrology

ISSN: 1471-2369

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