The association of angiogenic factors and chronic kidney disease

BMC Nephrology

Table 4 Angiogenesis-related factors according to chronic kidney disease stage

	Multivariable-adjusted median (IQR)^a			p-value
	Non-CKD controls (N = 201)	CKD Stage 3 (N = 142)	CKD Stage 4/5 (N = 59)	p-value
VEGF-A, pg/mL	114.17 (72.45, 170.32)	128.71 (89.19, 214.49)	134.27 (95.73, 178.73)	0.001
Angiopoeitin-1, pg/mL	4270.5 (2763.7, 6537.2)	4026.3 (2511.6, 6881.9)	3753.5 (2423.0, 6181.4)	0.44
Angiopoeitin-1/VEGF-A	36.55 (25.71, 61.10)	26.36 (18.82, 50.19)	23.47 (16.83, 42.51)	0.001
VEGFR-1, ng/mL	144.16 (123.74, 168.05)	135.96 (118.60, 160.40)	163.96 (135.19, 184.76)	0.04
VEGFR-2, ng/mL	26.28 (23.10, 29.69)	25.78 (22.23, 29.68)	27.85 (23.12, 31.10)	0.19
Pentraxin-3, ng/mL	0.89 (0.58, 1.18)	1.01 (0.79, 1.38)	1.04 (0.78, 1.58)	0.06

^aAdjusted for age, race, gender, current cigarette smoking, weekly alcohol consumption, physical activity ≥twice/week, BMI, LDL-cholesterol, HDL-cholesterol, C-reactive protein, fasting plasma glucose, systolic BP, use of aspirin or lipid-lowering, antihypertensive, or antidiabetic medications, and history of CVD

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