Renal function markers and insulin sensitivity after 3 years in a healthy cohort, the EGIR-RISC study

BMC Nephrology

Table 2 Differences (95% confidence intervals) in 3-year insulin sensitivity indices (ISI and HOMA-IS) and their 3-year changes (ΔISI, ΔHOMA-IS) associated with one unit or class increase in baseline renal function parameters (estimated glomerular filtration rate (eGFR), urinary creatinine ratio (UACR)) Model 1: adjusted for recruitment centre (random effect) and age; Model 2: additionally adjusted for significant baseline variables, as indicated in the footnote^a. The EGIR-RISC Study - Men

	ln (ISI year 3)		Ln (HOMA-IS year 3)		ΔISI		ΔHOMA-IS
	difference (95% CI)	P	difference (95% CI)	P	difference (95% CI)	P	difference (95% CI)	P
eGFR (ml/min/1.73 m²)	n = 376		n = 392		n = 349		n = 380
Model 1	trend	0.34	trend	0.35	trend	0.11	trend	0.47
eGFR> 105	.15 (.01, .30)	0.041	.093 (.030,.157)	0.004	1.5 (.2, 2.8)	0.015	2.1 (−1.2, 5.4)	0.21
eGFR 90–105	0		0		0		0
eGFR < 90	.14 (−.05, .33)	0.13	.094 (.014, .173)	0.021	.65 (−.90, 2.20)	0.41	1.7 (−2.6,6.0)	0.43
Model 2^a	trend	0.44	trend	0.66	trend	0.11	trend	0.21
eGFR > 105	.10 (−.01,.21)	0.069	.064 (.014, .115)	0.011	1.6 (.4, 2.9)	0.010	3.2 (−.1,6.5)	0.053
eGFR 90–105	0		0		0		0
eGFR < 90	.038 (−.097, .174)	0.58	.058 (−.004, .121)	0.064	.75 (−.80, 2.30)	0.34	1.6 (−2.6, 5.7)	0.45
UACR (mg/mmol)	n = 376		n = 392		n = 349		n = 380
Model 1	trend	0.026	trend	0.001	trend	0.49	trend	0.22
UACR not detected	0		0		0		0
UACR detected but < 0.26	−.002 (−.153, .149)	0.98	.032 (−.033, .098)	0.33	−.57 (−1.84, 0.72)	0.39	−.26 (−3.72, 3.21)	0.88
UACR ≥ 0.26	.16 (.00, .31)	0.039	.10 (.03,.17)	0.002	.34 (−.92, 1.62)	0.59	1.9 (−1.4, 5.4)	0.26
Model 2^a	trend	0.38	trend	0.009	trend	0.38	trend	0.050
UACR not detected	0		0		0		0
UACR detected but < 0.26	−.027 (−.139, .084)	0.63	.026 (−.024, .077)	0.31	−.51 (−1.78, .78)	0.44	.66 (−2.70,4.03)	0.70
UACR≥ 0.26	.042 (−.068, .152)	0.45	.064 (.014, .114)	0.011	.47 (−.80,1.74)	0.47	3.2 (−.1,6.5)	0.062

^aMultivariable models adjusted on age and recruitment centre, and on other significant covariates:
ln (ISI year3) and eGFR, adjusted on: HDL-cholesterol, trigylcerides, adiponectin, leptin ALAT, Il-6
ln (ISI year3) and UACR, adjusted on: HDL-cholesterol, trigylcerides, adiponectin, leptin ALAT
ln (HOMA-IS year 3) and eGFR, adjusted on: alcohol consumption, triglycerides, adiponectin, leptin, ALAT, IL-6
ln (HOMA-IS year 3) and UACR, adjusted on: alcohol consumption, heart rate, HDL-cholester ol, triglycerides, adiponectin, leptin, ALAT
ΔISI and eGFR, UACR, adjusted on: leptin
ΔHOMA-IS and eGFR, UACR, adjusted on: alcohol consumption, GGT

ISSN: 1471-2369