Renal function markers and insulin sensitivity after 3 years in a healthy cohort, the EGIR-RISC study

BMC Nephrology

Table 3 Differences (95% confidence intervals) in 3-year insulin sensitivity indices (ISI and HOMA-IS) and their 3-year changes (ΔISI, ΔHOMA-IS) associated with one unit or class increase in baseline renal function parameters (estimated glomerular filtration rate (eGFR), urinary creatinine ratio (UACR)) Model 1: adjusted for recruitment centre (random effect) and age; Model 2: additionally adjusted for significant baseline variables, as indicated in the footnote^a. The EGIR-RISC Study - Women

	ln (ISI year 3)		ln (HOMA-IS year 3)		ΔISI		ΔHOMA-IS
	difference (95% CI)	P	difference (95% CI)	P	difference (95% CI)	P	difference (95% CI)	P
eGFR (ml/min/1.73 m²)	n = 492		n = 514		n = 448		n = 501
Model 1	trend	0.050	trend	0.15	trend	0.46	trend	0.40
eGFR > 105	−.086 (−.200, .028)	0.14	−.027 (−.150, .096)	0.67	.81 (−.35, 1.97)	0.17	2.5 (0.2, 4.8)	0.032
eGFR 90–105	0		0		0		0
eGFR < 90	.050 (−.101, .201)	0.51	.072 (−.084, .228)	0.37	1.1 (−.4, 2.6)	0.12	.74 (−2.10, 3.58)	0.61
Model 2^a	trend	0.29	trend	0.55	trend	0.55	trend	0.55
eGFR > 105	−.050 (−.146, .047)	0.31	−.010 (.-.11, .09)	0.84	.76 (−.37, 1.91)	0.19	2.19 (−0.06, 4.44)	0.057
eGFR 90–105	0		0		0		0
eGFR < 90	.011 (−.108, .131)	0.86	.016 (−.110, .141)	0.81	1.02 (−.37, 2.42)	0.15	.75 (−2.06, 3.57)	0.60
UACR (mg/mol)	n = 486		n = 507		n = 442		n = 494
Model 1	trend	0.009	trend	0.023	trend	0.063	trend	0.004
UACR not detected	ref		ref		ref		ref
UACR detected but < 0.36	.11 (−.01, .24)	0.080	.11 (−.02, .24)	0.10	.57 (−.60, 1.75)	0.34	.69 (−1.66, 3.03)	0.56
UACR≥ 0.36	.16 (.04, .29)	0.008	.15 (.02 .28)	0.021	1.11 (−0.06, 2.29)	0.064	3.33 (.99, 5.698)	0.005
Model 2^a	trend	0.029	trend	0.21	trend	0.044	trend	0.007
UACR not detected	ref		ref		ref		ref
UACR detected but < 0.36	.044 (−.056, .145)	0.38	.022 (−.080, .125)	0.67	.69 (−.48, 1.85)	0.25	.56 (−1.77, 2.88)	0.64
UACR ≥ 0.36	.11 (.008, .21)	0.032	.063 (−.038, .164)	0.22	1.20 (.03, 2.37)	0.044	3.1 (0.7, 5.4)	0.010

^aMultivariable models adjusted on age and recruitment centre, and on other significant covariates:
Ln(ISI year 3) and eGFR, adjusted on: current smoker, BMI, heart rate, HDL cholesterol, triglycerides, adiponectin, leptin, GGT
Ln(ISI year 3) and UACR, adjusted on: current smoker, BMI, heart rate, HDL cholesterol, triglycerides, adiponectin, leptin
Ln(HOMA-IS year 3) and eGFR adjusted on: physical activity, BMI, heart rate, HDL-cholesterol, triglycerides, adiponectin, leptin
Ln(HOMA-IS year 3) and UACR adjusted on: alcohol consumption, physical activity, BMI, heart rate, HDL-cholesterol, triglycerides,
adiponectin, leptin
ΔISI and eGFR, UACR, adjusted on: LDL-cholesterol, ALAT
ΔHOMA-IS and eGFR, UACR, adjusted on: LDL-cholesterol

ISSN: 1471-2369