Table 2 Recent studies of hypercalcemia treatment by prolonged intermittent or continuous RRT
Author, year | No. | Citrate dosea (mmol/L) | Calcium doseb (mmol/h) | Mode, blood flow (mL/min) | Dose (L/h) | Ionized Calcium (mmol/L) | Calcium lossc (mmol/h) | Adverse effect |
|---|---|---|---|---|---|---|---|---|
Low-calcium HD | Suppose ionized calcium reduced from 1.9 to 1.3 mmol/L after the dialyzer, blood flow was 150 mL/min and dialysate flow was 500 mL/min | 1.90 | 5.40 | No | ||||
Calcium-free HD [5] | Suppose ionized calcium reduced from 1.9 to 0.5 mmol/L after the dialyzer, blood flow was 150 mL/min and dialysate flow was 500 mL/min | 1.90 | 12.6 | Frequent | ||||
V.sramek 1998 [9] | 1 | 3.7–6.1 | 0 | CVVHDF, 100 | 3 | 2.0d | 6.30 | No |
Mlles 2008 [8] | 1 | 4.3 | 1.2 | CVVHD, 200 | 2.2 | 1.77 | 2.91 | No |
Au 2012 [6] | 1 | – | 0 | CVVH, 150 | 2 | 2.19 | 4.38 | No |
Matis 2015 [7] | 4 | 3 | 1.5–2.3 | CVVHDF, 180 | 3.7 | 1.72 | 5.23 | No |
3 | 1.3 | CVVHDF, 100 | 2.5 | 1.90 | 3.70 | Hypocalcemia | ||
3–3.5 | 2–2.75 | CVVHDF, 100 | 2.5 | 1.79 | 2.48 | No | ||
3 | 1.5 | CVVHDF, 100 | 2.5 | 1.80 | 3.00 | Hypocalcemia | ||
3 | 1.4 | CVVHDF, 100 | 2.5 | 2.09 | 3.82 | No | ||
The present study | 1 | |||||||
Second session | 4.2 | 1.1(at start) | HF, 120 | 4.3 | 1.91 | 7.54 | Arrhythmia | |
Third session | 4.2 | 2.2 | HF, 120 | 4.3 | 1.91 | 6.44 | No | |