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Table 3 Enrichment analysis of genes in each functional interaction network module
| Module | GeneSet | FDR | Genes |
|---|---|---|---|
| a | Integration of energy metabolism(R) | 8.62 × 10−5 | STK11, GNG10, GNB4, PRKACA |
| a | Morphine addiction(K) | 8.62 × 10− 5 | GNG10, GNB4, PDE4D, PRKACA |
| a | Glutamatergic synapse(K) | 1.39 × 10−4 | GNG10, GNB4, PRKACA, GRIN3A |
| b | GPCR ligand binding(R) | 7.31 × 10−7 | PTGIR, CCL20, LPAR6, FFAR2, FPR2, NTSR1, NPFF |
| b | GPCR downstream signaling(R) | 4.07 × 10−6 | PTGIR, CCL20, LPAR6, FFAR2, GNA11, FPR2, NTSR1, NPFF |
| b | Gastrin-CREB signaling pathway via PKC and MAPK(R) | 6.99 × 10−6 | LPAR6, FFAR2, GNA11, FPR2, NTSR1, NPFF |
| c | overview of telomerase rna component gene hterc transcriptional regulation(B) | 1.29 × 10−2 | NFYB |
| c | DNA Double Strand Break Response(R) | 1.62 × 10−2 | KDM4B |
| c | Regulation of cholesterol biosynthesis by SREBP (SREBF)(R) | 1.62 × 10−2 | NFYB |
| d | Alcoholism(K) | 1.74 × 10−10 | HIST1H2AC, HIST2H2BE, H2AFY2, HIST1H2BH, HDAC10, HIST3H2A |
| d | Systemic lupus erythematosus(K) | 6.92 × 10−9 | HIST1H2AC, HIST2H2BE, H2AFY2, HIST1H2BH, HIST3H2A |
| d | Chromatin modifying enzymes(R) | 1.55 × 10−4 | HIST2H2BE, HIST1H2BH, HDAC10 |
