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Table 3 Summary of prediction improvement assessments comparing models with and without hematuria for halving of eGFR, ESRD and death

From: Hematuria as a risk factor for progression of chronic kidney disease and death: findings from the Chronic Renal Insufficiency Cohort (CRIC) Study

  C-statistics Three categories NRI (95%CI) Category-Free NRI (95%CI)
Hematuria Increase Events Non-events Overall Events Non-events Overall
No Yes        
Halving of eGFR/ESRDa 0.897 0.898 0.001 −0.01 (−0.04 to 0.02) 0.01 (−0.01 to 0.02) 0.00 (−0.04 to 0.03) 0.29 (0.18 to 0.41) 0.35 (0.23 to 0.47) 0.64 (0.44 to 0.84)
ESRDb 0.929 0.931 0.002 0.01 (−0.04 to 0.05) 0.01 (−0.01 to 0.02) 0.01 (−0.03 to 0.06) 0.41 (0.28 to 0.55) 0.22 (0.01 to 0.42) 0.63 (0.35 to 0.91)
Deathc 0.770 0.782 0.012 0 (−0.10 to 0.10) 0.01 (−0.02 to 0.04) 0.01 (− 0.10 to 0.12) 0.04 (− 0.14 to 0.22) 0.38 (0.33 to 0.43) 0.42 (0.22 to 0.62)
  1. Halving of eGFR or ESRD: model includes: age, race, sex, eGFR, albuminuria, diabetes, systolic blood pressure, BMI, waist circumference, NT-pro-BNP, serum albumin. ESRD: model includes age, sex, eGFR, albuminuria, diabetes, waist circumference, NT-pro-BNP, FGF-23, Calcium, iPTH, serum albumin, uric acid, triglycerides. Death: model includes BMI, history of CVD, High-sensitive Troponin T, NT-pro-BNP, high sensitivity CRP, use of ACE/ARBs. Categories of predicted probability of the outcome used in the three category NRI: 0 to 10%; > 10 to 15%; > = 15% for halving of eGFR/ESRD; 0 to 5%; > 5 to 10%; > = 10% for ESRD; 0 to 3%; > 3 to 8%; > = 8% for death