Fig. 1

Pathological examination of renal biopsy specimen. a PAS revealed an intra-capillary PAS-positive material in a glomerulus (arrow). Extensive capillary duplication can also be observed (PAS × 400). b Extensive fuchsinophilic deposits in the subendothelial (long arrow) and mesangium (short arrow) were seen (Masson× 400). c Immunofluorescence staining for C3 is strongly positive in the mesangium and along the basement membrane. d Electron microscopy demonstrated extensive subendothelial (red arrows) and subepithelial electron-dense deposits (thin black arrow). New membrane formation (fat black arrow) and wide spread foot process effacement are evident. e Subendothelial lucency, a characteristic finding in TMA, can be seen in the glomerular tuft. f Review of the first biopsy slide provided. The staining quality is suboptimal, however, thrombus (arrow) at arteriole can be clearly identified. The glomerulus exhibited MPGN-like pattern (Masson× 400)