Fig. 5
From: Rehydration with fructose worsens dehydration-induced renal damage
Inflammasome Activation in a Rat Model of Heat Stress. Protein lysates from the kidneys of a rat model of heat stress [24] were used to confirm whether rehydration with fructose containing solutions can increase the expression for inflammasome and apoptosis markers in the kidney. Heat stress with water rehydration could induce an increase in NRLP3, Caspase-3, and IL-1β protein in renal tissues compared to normal controls. However, when rats were rehydrated with fructose (10% in the drinking water), the expression of these inflammasome markers increased markedly and were significantly greater than rehydration with water alone. N = 4 per group