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Table 1 Relative proteins expression and apoptosis in control and treated podocytes

From: Angiotensin II-induced podocyte apoptosis is mediated by endoplasmic reticulum stress/PKC-δ/p38 MAPK pathway activation and trough increased Na+/H+ exchanger isoform 1 activity

  Ctl AII (1 μM) AII/Los (1 μM) AII/SB (0.1 μM) n
Protein
 GRP 78 1.00 ± 0.00 1.71 ± 0. 15a 1.05 ± 0.01d 4
 peIF2-α 1.00 ± 0.00 1.87 ± 0. 21b 1.12 ± 0.09f 4
 pPKC-δ 1.00 ± 0.00 1.59 ± 0.04a 1.05 ± 0.10d 5
 pP38MAPK 1.00 ± 0.00 1.70 ± 0.03a 0.94 ± 0.06d 4
 Total Bax 1.00 ± 0.00 1.64 ± 0.11a 0.95 ± 0.03d 4
 Total Bcl-2 1.00 ± 0.00 1.19 ± 0.07 1.04 ± 0.03 4
 Bax/Bcl-2 ratio 1.00 ± 0.00 1.39 ± 0.08a 0.90 ± 0.01d 4
Cell Viability %
 Viable 90.93 ± 0.70 87.34 ± 0.59c 92.65 ± 0.73d 5–6
 Early apoptosis 0.62 ± 0.06 0.80 ± 0.07 0.43 ± 0.03f 5–6
 Late Apoptosis 4.99 ± 0.28 6.99 ± 0.50b 4.61 ± 0.30e 5–6
 Necrosis 3.43 ± 0.47 3.97 ± 0.36 2.48 ± 0.41 5–6
  1. Values are means ± SEM. n, number of experiments. ap < 0.001, bp < 0.01 and cp < 0.01 versus control (Ctl); dp < 0.001, ep < 0.01 and fp < 0.05 versus angiotensin II (Ang II); Los losartan, SB SB203580; p phosphorylated protein expression