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Table 3 Use of second-line immunosuppressants

From: Adult minimal-change disease: observational data from a UK centre on patient characteristics, therapies, and outcomes

Immunosuppressant

N (%) of cohort treated

Duration of therapy

Achieved CR (N)

Relapsed (N)

Time to relapse (months)

Calcineurin inhibitors

25 (32)

18 (10–34)a

21

16

7 (2–22)

Cyclophosphamide

10 (13)

9 (8–10)b

9

6

20 (5–44)

Levamisole

7 (9)

7 (4–38)b

6

5

10 (3–14)

Mycophenolate mofetil

6 (8)

10 (3–29)a

4

3

47 (25–56)

Rituximab

4 (5)

N/A

4

0

N/A

  1. The table shows the number (percentage) of the total cohort treated with each class of immunosuppressant, with the median (IQR) duration of the course, and the number who achieved complete remission. The number who went on to relapse is shown, with the median (IQR) time to relapse. Cyclophosphamide was given orally in all cases. If a patient received more than one course of a particular class of agent, the median therapy duration of therapy and the remission/relapse rates relate to the first course given. amonths; bweeks