Fig. 5
Predicted incidence rates of RAASi discontinuation, disaggregated by eGFR (a), diuretics usage (b), presence of diabetes (c), and sex (d). a light grey line: 15 mL/min/1.73m2, dark grey line: 30 mL/min/1.73m2, black line: 60 mL/min/1.73m2. b grey line: yes, black line: no. c grey line: yes, black line: no. d grey line: male, black line: female. The four most important variables for each event (according to the absolute value of the t statistic) were varied, with all other baseline covariates reflective of the cohort average: female; aged 72 years; non-smoker; no history of comorbidities; no medications prescribed; 1066 days elapsed since initial CKD event; no history of heart failure during follow-up period; eGFR 51 mL/min/1.73m2; BMI 29 kg/m2; haemoglobin 13.6 g/dL; total cholesterol 4.98 mmol/L. BMI: body mass index; CKD: chronic kidney disease; eGFR: estimated glomerular filtration rate; RAASi: renin-angiotensin-aldosterone system inhibitor