Table 2 Associations of multi-marker panel, individuals’ biomarkers and multi-marker scores with incident CKD and rapid kidney function decline

Entire panel

2.72 (1.63, 4.56)

0.001

2.61 (1.67, 4.08)

0.001

 Continuous

1.24 (1.07, 1.44)

0.005

1.22 (1.06, 1.40)

0.006

 Q1

54/703

Reference

63/703

Reference

 Q2

71/703

1.37 (0.89, 2.09)

0.151

78/703

1.20 (0.83, 1.75)

0.330

 Q3

72/704

1.31 (0.85, 2.02)

0.217

72/704

1.14 (0.77, 1.67)

0.515

 Q4

98/703

1.66 (1.08, 2.55)

0.022

97/703

1.49 (1.02, 2.18)

0.045

 Continuous

1.31 (1.06, 1.61)

0.011

1.12 (0.93, 1.34)

0.234

 Q1

54/698

Reference

…

67/698

Reference

…

 Q2

79/711

1.37 (0.89, 2.11)

0.151

77/711

1.13 (0.77, 1.66)

0.525

 Q3

73/699

1.52 (0.95, 2.42)

0.079

90/699

1.64 (1.10, 2.44)

0.015

 Q4

89/705

2.00 (1.18, 3.38)

0.009

76/705

1.29 (0.80, 2.06)

0.295

 Continuous

1.13 (0.96, 1.33)

0.149

1.17 (1.01, 1.36)

0.031

 Q1

53/700

Reference

…

56/700

Reference

…

 Q2

88/707

1.22 (0.80, 1.87)

0.358

81/707

1.12 (0.76, 1.65)

0.572

 Q3

85/705

1.32 (0.86, 2.02)

0.212

88/705

1.25 (0.85, 1.84)

0.258

 Q4

69/701

1.13 (0.71, 1.80)

0.593

85/701

1.28 (0.85, 1.92)

0.230

 Continuous

0.92 (0.8,1.06)

0.229

0.85 (0.74, 0.96)

0.012

 Q1

77/698

Reference

…

93/698

Reference

…

 Q2

68/720

0.82 (0.55, 1.23)

0.347

80/720

0.88 (0.62,1.24)

0.461

 Q3

58/707

0.54 (0.35, 0.82)

0.004

66/707

0.66 (0.46, 0.95)

0.026

 Q4

92/688

0.68 (0.46, 1.04)

0.077

71/688

0.62 (0.43, 0.89)

0.009

 0

40/651

Reference

42/651

Reference

 1

53/652

1.48 (0.94–2.33)

0.093

54/652

1.12 (0.75–1.67)

0.586

 2

73/652

2.02 (1.30–3.14)

0.002

74/652

1.62 (1.11–2.37)

0.001

 3

90/652

2.45 (1.53–3.91)

<.001

95/652

2.04 (1.40–2.99)

<.001