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Fig. 5 | BMC Nephrology

Fig. 5

From: The two isoforms of matrix metalloproteinase- 2 have distinct renal spatial and temporal distributions in murine models of types 1 and 2 diabetes mellitus

Fig. 5

PAS and Masson trichrome staining of kidneys from the STZ model of Type 1 diabetes mellitus. Panel I: PAS staining of renal cortex at 4, 8 and 24 weeks after STZ treatment. PAS staining is normal in the 4 week STZ group, while vacuolization of tubular epithelial cells is present at 8 weeks (arrow). By 24 weeks there is widespread tubular epithelial cell necrosis with cellular debris in the tubular lumens (arrows). Panel II: Masson trichrome staining of kidneys at 4, 8 and 24 weeks following STZ treatment. There is no detectable fibrosis at 4 and 8 weeks, while there are small foci of fibrosis (blue staining) in the cortex of kidneys at 24 weeks (inset X400)

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