Fig. 6

PAS and Masson trichrome staining of kidneys from the db/db model of Type 2 diabetes mellitus. Panel I: PAS staining of control db/m kidneys is normal. At 10 weeks of age kidneys of db/db mice show occasional tubular epithelial cell vacuolization (arrow), which is much more extensive at 16 weeks of age (arrows). Panel II. Masson trichrome staining of control db/db kidneys at 10 and 16 weeks of age. There are rare, scattered foci of fibrosis (blue) in the deep cortex at 16 weeks, but not at 10 weeks of age (inset X400)