Table 1 Charateristics of diabetic mice models
DM | variables | control (12wks) | STZ 4wks | STZ 8wks | STZ 12wks | STZ 24wks | p-value | |
Type 1 | BW (gm) | Initial | 23(23–23.8) | 23.5(23–24) | 23.5(22.8–24) | 23(23–23) | 23(23–24) | 0.684 |
Last | 31(29.2–32.8) | 27(26.3–27.3) | 26(25–28.5) | 26(25–27.8) | 29(27–32) | 0.001 | ||
KW/BW (mg/mg) | 0.005 (0.005–0.006) | 0.008 (0.007–0.010) | 0.008 (0.008–0.008) | 0.008 (0.007–0.008) | 0.009 (0.008–0.011) | < 0.001 | ||
ACR (μg/mg) | 48.0 (31.6–58.9) | 90.6 (78.5–97.5) | 70.3 (39.0–101.5) | 0.002 | ||||
DM | variables | control | db/db | db/db | p-value | |||
(db/m 10wks) | (10wks) | (16wks) | ||||||
Type 2 | BW | Initial | 24(24–26) | 45(45–46) | 45.5(43.5–47.5) | 0.043 | ||
Last | 25(25–28) | 48(45–49) | 55(50.5–58.8) | 0.001 | ||||
KW/BW (mg/mg) | 0.006 (0.005–0.008) | 0.004 (0.004–0.004) | 0.004 (0.004–0.005) | 0.045 | ||||
ACR (μg/mg) | 77.5 (75.9–84.2) | 1000 (702.5–2274.0) | 1333 (975.3–3755.0) | 0.05 |