|
DM
|
variables
| |
control (12wks)
|
STZ 4wks
|
STZ 8wks
|
STZ 12wks
|
STZ 24wks
|
p-value
|
|
Type 1
|
BW (gm)
|
Initial
|
23(23–23.8)
|
23.5(23–24)
|
23.5(22.8–24)
|
23(23–23)
|
23(23–24)
|
0.684
|
| |
Last
|
31(29.2–32.8)
|
27(26.3–27.3)
|
26(25–28.5)
|
26(25–27.8)
|
29(27–32)
|
0.001
|
|
KW/BW (mg/mg)
| |
0.005 (0.005–0.006)
|
0.008 (0.007–0.010)
|
0.008 (0.008–0.008)
|
0.008 (0.007–0.008)
|
0.009 (0.008–0.011)
|
< 0.001
|
|
ACR (μg/mg)
| |
48.0 (31.6–58.9)
| | |
90.6 (78.5–97.5)
|
70.3 (39.0–101.5)
|
0.002
|
|
DM
|
variables
| |
control
|
db/db
|
db/db
| | |
p-value
|
| | | |
(db/m 10wks)
|
(10wks)
|
(16wks)
| | | |
|
Type 2
|
BW
|
Initial
|
24(24–26)
|
45(45–46)
|
45.5(43.5–47.5)
| | |
0.043
|
| |
Last
|
25(25–28)
|
48(45–49)
|
55(50.5–58.8)
| | |
0.001
|
|
KW/BW (mg/mg)
| |
0.006 (0.005–0.008)
|
0.004 (0.004–0.004)
|
0.004 (0.004–0.005)
| | |
0.045
|
|
ACR (μg/mg)
| |
77.5 (75.9–84.2)
|
1000 (702.5–2274.0)
|
1333 (975.3–3755.0)
| | |
0.05
|
- Abbreviations: DM diabetes mellitus; STZ streptozotocin; BW body weight; KW/BW kidney weight/body weight; ACR albumin creatinine ratio
