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Table 1 Charateristics of diabetic mice models

From: The two isoforms of matrix metalloproteinase- 2 have distinct renal spatial and temporal distributions in murine models of types 1 and 2 diabetes mellitus

DM variables   control (12wks) STZ 4wks STZ 8wks STZ 12wks STZ 24wks p-value
Type 1 BW (gm) Initial 23(23–23.8) 23.5(23–24) 23.5(22.8–24) 23(23–23) 23(23–24) 0.684
  Last 31(29.2–32.8) 27(26.3–27.3) 26(25–28.5) 26(25–27.8) 29(27–32) 0.001
KW/BW (mg/mg)   0.005 (0.005–0.006) 0.008 (0.007–0.010) 0.008 (0.008–0.008) 0.008 (0.007–0.008) 0.009 (0.008–0.011) < 0.001
ACR (μg/mg)   48.0 (31.6–58.9)    90.6 (78.5–97.5) 70.3 (39.0–101.5) 0.002
DM variables   control db/db db/db    p-value
    (db/m 10wks) (10wks) (16wks)    
Type 2 BW Initial 24(24–26) 45(45–46) 45.5(43.5–47.5)    0.043
  Last 25(25–28) 48(45–49) 55(50.5–58.8)    0.001
KW/BW (mg/mg)   0.006 (0.005–0.008) 0.004 (0.004–0.004) 0.004 (0.004–0.005)    0.045
ACR (μg/mg)   77.5 (75.9–84.2) 1000 (702.5–2274.0) 1333 (975.3–3755.0)    0.05
  1. Abbreviations: DM diabetes mellitus; STZ streptozotocin; BW body weight; KW/BW kidney weight/body weight; ACR albumin creatinine ratio