The effect of sodium nitrite infusion on renal function, brachial and central blood pressure during enzyme inhibition by allopurinol, enalapril or acetazolamide in healthy subjects: a randomized, double-blinded, placebo-controlled, crossover study

Table 6 Effect of intravenous NaNO₂ on the renin-angiotensin-aldosteron system

	Baseline	Infusion		p _{RM ANOVA (one-way)}
	Baseline	60 min	120 min	p _{RM ANOVA (one-way)}
PRC (pg/ml)
Placebo	9 (6;14)	9 (7;16)	9 (8;16)	.262
Allopurinol	9 (5;12)	9 (6;16)^*	10 (6;14)	.024
Enalapril	54 (27;89)^†	72 (40;93)^*	69 (61;95)^*	.014
Acetazolamide	15 (9;20)^†	16 (12;23)	18 (12;23)^*	.008
p_{interaction (pretreatment x time)}		.168
P-AngII (pg/ml)
Placebo	16 (12;22)	17 (13;20)	14 (11;23)	.239
Allopurinol	14 (8;19)^†	14 (12;21)	13 (10;19)	.175
Enalapril	11 (6;17)^†	13 (8;21)	11 (8;21)	.189
Acetazolamide	19 (11;34)	20 (14;34)^*	21 (16;35)^*	.001
p_{interaction (pretreatment x time)}		.160
P-Aldo (pmol/l)
Placebo	128 (98;161)	121 (90;155)	106 (79;155)	.228
Allopurinol	105 (82;158)	98 (64;138)	113 (76;147)	.967
Enalapril	78 (56;106)	77 (54;97)	71 (59;117)	.511
Acetazolamide	184 (132;281)^†	178 (125;308)	230 (110;352)	.826
p_{interaction (pretreatment x time)}		.664

Effect of intravenous NaNO₂ on plasma concentrations of renin (PRC), angiotensin II (P-AngII), and aldosterone (P-Aldo) in 16 healthy subjects after 4 days pretreatment with allopurinol, enalapril, acetazolamide, or placebo. Data are medians with 25th and 75th percentiles in parentheses. After log transformation, statistics were performed using one-way repeated measures (RM) ANOVA for comparing over time and two-way RM ANOVA with time and pretreatment as within factors to test for interaction. Pairwise comparison with placebo or baseline where performed using Student’s t-test after log transformation
^* p < .05 within group vs. baseline (Bonferroni), ^† p < .05 vs. placebo at baseline

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