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Table 1 Demografic and biochemical data

From: Activation of RAAS in a rat model of liver cirrhosis: no effect of losartan on renal sodium excretion

 

Unit

Sham + placebo

Sham + losartan

BDL + placebo

BDL + losartan

Initial number rats

N

8

8

10

10

Mortality

N

0

0

3

6

Rats with/ without ascites

N

0\8

0\8

7\1

3\3

Preoperative weight

g

237 ± 5

243 ± 9

240 ± 4

237 ± 7

Final weight

g

346 ± 14

366 ± 15

325 ± 5

317 ± 9

Final weight (dry)

g

346 ± 14

366 ± 15

317 ± 6

314 ± 8

Weight gain (dry)

g

109 ± 13

123 ± 12

77 ± 5

77 ± 8

Liver

(g/100gBW)

3.37 ± 0.17†††

3.31 ± 0.05†††

7.41 ± 0.37

7.09 ± 0.22

Spleen

(g/100gBW)

0.19 ± 0.01†††

0.19 ± 0.004†††

0.62 ± 0.02

0.50 ± 0.05*

Kidney

(g/100gBW)

0.56 ± 0.08††

0.60 ± 0.01

0.76 ± 0.01

0.80 ± 0.03

Heart

(g/100GBW)

0.27 ± 0.01

0.25 ± 0.01††

0.33 ± 0.02

0.28 ± 0.02

Adrenal gland

(g/100gBW)

0.016 ± 0.001

0.015 ± 0.001

0.018 ± 0.001

0.018 ± 0.001

B-Haemoglobin

mmol/L

9.7 ± 0.1

9.7 ± 0.1

9.6 ± 0.4

9.9 ± 0.6

B-Haematocrit

%

47 ± 1

46 ± 1

49 ± 1

49 ± 3

B-Leucocytes

10*9/L

5.8 ± 0.4†††

6.3 ± 0.3†††

26.0 ± 2.3

23.9 ± 4.7

B-Platelets

10*9/L

791 ± 33

769 ± 41

567 ± 113

597 ± 56

S-Bilirubin

μmol/l

1.3 ± 0.16†††

0.8 ± 0.17†††

188.6 ± 10.8

227.3 ± 18.6

S-Albumin

μmol/l

667.3 ± 35.7†††

607.6 ± 23.1

475.0 ± 25.2

514.8 ± 18.4

S-Creatinine

μmol/l

17.6 ± 0.6

16.3 ± 2.1

18.3 ± 1.3

21.5 ± 2.6

P-Osmolality

mOsm/kg

305 ± 2

306 ± 2

300 ± 1

304 ± 2

P-Sodium

mmol/l

139 ± 1.0

139 ± 0.8

141 ± 0.4

140 ± 0.9

P-Potassium

mmol/l

6.3 ± 0.2

6.5 ± 0.4

5.8 ± 0.2

7.1 ± 0.5*

  1. Values are given as mean ± SEM. *p < 0.05: BDL placebo vs. BDL losartan. p < 0.05: Sham vs. BDL, ††p < 0.01 Sham vs. BDL, †††p < 0.001: Sham vs. BDL