Parameters | All patients (Nā=ā83) | GFR decline < 25% per year (Nā=ā46) | GFR decline ā„ 25% per year (Nā=ā37) | P-value |
---|---|---|---|---|
Age (year) | 66.6āĀ±ā9.8 | 67.1āĀ±ā8.9 | 65.9āĀ±ā10.9 | 0.595 |
Male (%) | 53 (63.9%) | 29 (63.0%) | 24 (64.9%) | 0.864 |
Duration of DM (years) | 13.9āĀ±ā8.9 | 14.8āĀ±ā8.3 | 13.2āĀ±ā9.6 | 0.463 |
CKD staging | ||||
āCKD I | 7 (8.4%) | 4 (8.7%) | 3 (8.1%) | 0.065 |
āCKD II | 19 (22.9%) | 14 (30.4%) | 5 (13.5%) | Ā |
āCKD III | 26 (31.3%) | 17 (36.9%) | 9 (24.3%) | Ā |
āCKD IV | 16 (19.3%) | 5 (10.9%) | 11 (29.7%) | Ā |
āCKD V | 15 (18.1%) | 6 (13.0%) | 9 (24.3%) | Ā |
Comorbid diseases | ||||
āHypertension (%) | 79 (96.3%) | 44 (95.7%) | 35 (94.6%) | 0.586 |
āDyslipidemia (%) | 72 (87.8%) | 43 (95.6%) | 29 (78.4%) | 0.037 |
āHistory of cardiovascular events (%) | 3 (3.7%) | 2 (4.4%) | 1 (2.7%) | 1.000 |
āFramingham risk score | 15.63āĀ±ā10.29 | 13.83āĀ±ā8.07 | 17.76āĀ±ā12.22 | 0.152 |
āHigh cardiovascular riska (%) | 37 (44.6%) | 21 (45.7%) | 16 (43.2%) | 0.605 |
āAnemia (%) | 51 (61.5%) | 22 (47.8%) | 29 (78.4%) | 0.004 |
Medications | ||||
āRAAS blockers (%) | 45 (54.2%) | 27 (58.7%) | 18 (48.7%) | 0.361 |
āInsulin (%) | 29 (35.4%) | 14 (31.1%) | 15 (40.5%) | 0.374 |
āASA (%) | 50 (60.9%) | 28 (62.2%) | 22 (59.5%) | 0.799 |
Clinical parameters | ||||
āSBP (mmHg) | 143.1āĀ±ā22.4 | 135.5āĀ±ā16.3 | 152.4āĀ±ā25.4 | 0.001 |
āDBP (mmHg) | 77.7āĀ±ā13.9 | 74.8āĀ±ā12.2 | 81.2āĀ±ā15.2 | 0.037 |
āBMI (kg/m2) | 27.5āĀ±ā5.0 | 27.3āĀ±ā5.2 | 27.73āĀ±ā4.9 | 0.736 |
Laboratory parameters | ||||
āGFR (mL/min/1.73m2) | 45.0āĀ±ā28.4 | 51.9āĀ±ā27.6 | 36.4āĀ±ā27.4 | 0.012 |
āMedian UACR (mg/g creatinine) | 283.7 [34.5, 762.9] | 49.7 [19.9, 261.3] | 673.4 [412.6, 2627.6] | <ā0.001 |
āFPG (mg/dL) | 150.6āĀ±ā74.7 | 146.4āĀ±ā78.9 | 155.8āĀ±ā69.8 | 0.574 |
āHbA1c (%) | 7.4āĀ±ā1.6 | 7.4āĀ±ā1.7 | 7.4āĀ±ā1.5 | 0.931 |
āHemoglobin (g/dL) | 11.9āĀ±ā3.1 | 12.2āĀ±ā1.7 | 11.7āĀ±ā4.2 | 0.517 |
āPhosphate (mg/dL) | 3.5āĀ±ā0.9 | 3.7āĀ±ā0.9 | 3.4āĀ±ā0.8 | 0.167 |
āMedian intact-PTH (pg/mL) | 120.5 [66.9, 256.6] | 133.55 [63.9, 269.2] | 120.5 [70.6, 214.1] | 0.887 |