Skip to main content

Table 1 Baseline characteristics and laboratory data

From: Urinary epidermal growth factor, monocyte chemoattractant protein-1 or their ratio as predictors for rapid loss of renal function in type 2 diabetic patients with diabetic kidney disease

Parameters

All patients (Nā€‰=ā€‰83)

GFR decline

< 25% per year (Nā€‰=ā€‰46)

GFR decline

ā‰„ 25% per year (Nā€‰=ā€‰37)

P-value

Age (year)

66.6ā€‰Ā±ā€‰9.8

67.1ā€‰Ā±ā€‰8.9

65.9ā€‰Ā±ā€‰10.9

0.595

Male (%)

53 (63.9%)

29 (63.0%)

24 (64.9%)

0.864

Duration of DM (years)

13.9ā€‰Ā±ā€‰8.9

14.8ā€‰Ā±ā€‰8.3

13.2ā€‰Ā±ā€‰9.6

0.463

CKD staging

ā€ƒCKD I

7 (8.4%)

4 (8.7%)

3 (8.1%)

0.065

ā€ƒCKD II

19 (22.9%)

14 (30.4%)

5 (13.5%)

Ā 

ā€ƒCKD III

26 (31.3%)

17 (36.9%)

9 (24.3%)

Ā 

ā€ƒCKD IV

16 (19.3%)

5 (10.9%)

11 (29.7%)

Ā 

ā€ƒCKD V

15 (18.1%)

6 (13.0%)

9 (24.3%)

Ā 

Comorbid diseases

ā€ƒHypertension (%)

79 (96.3%)

44 (95.7%)

35 (94.6%)

0.586

ā€ƒDyslipidemia (%)

72 (87.8%)

43 (95.6%)

29 (78.4%)

0.037

ā€ƒHistory of cardiovascular events (%)

3 (3.7%)

2 (4.4%)

1 (2.7%)

1.000

ā€ƒFramingham risk score

15.63ā€‰Ā±ā€‰10.29

13.83ā€‰Ā±ā€‰8.07

17.76ā€‰Ā±ā€‰12.22

0.152

ā€ƒHigh cardiovascular riska (%)

37 (44.6%)

21 (45.7%)

16 (43.2%)

0.605

ā€ƒAnemia (%)

51 (61.5%)

22 (47.8%)

29 (78.4%)

0.004

Medications

ā€ƒRAAS blockers (%)

45 (54.2%)

27 (58.7%)

18 (48.7%)

0.361

ā€ƒInsulin (%)

29 (35.4%)

14 (31.1%)

15 (40.5%)

0.374

ā€ƒASA (%)

50 (60.9%)

28 (62.2%)

22 (59.5%)

0.799

Clinical parameters

ā€ƒSBP (mmHg)

143.1ā€‰Ā±ā€‰22.4

135.5ā€‰Ā±ā€‰16.3

152.4ā€‰Ā±ā€‰25.4

0.001

ā€ƒDBP (mmHg)

77.7ā€‰Ā±ā€‰13.9

74.8ā€‰Ā±ā€‰12.2

81.2ā€‰Ā±ā€‰15.2

0.037

ā€ƒBMI (kg/m2)

27.5ā€‰Ā±ā€‰5.0

27.3ā€‰Ā±ā€‰5.2

27.73ā€‰Ā±ā€‰4.9

0.736

Laboratory parameters

ā€ƒGFR (mL/min/1.73m2)

45.0ā€‰Ā±ā€‰28.4

51.9ā€‰Ā±ā€‰27.6

36.4ā€‰Ā±ā€‰27.4

0.012

ā€ƒMedian UACR (mg/g creatinine)

283.7 [34.5, 762.9]

49.7 [19.9, 261.3]

673.4 [412.6, 2627.6]

<ā€‰0.001

ā€ƒFPG (mg/dL)

150.6ā€‰Ā±ā€‰74.7

146.4ā€‰Ā±ā€‰78.9

155.8ā€‰Ā±ā€‰69.8

0.574

ā€ƒHbA1c (%)

7.4ā€‰Ā±ā€‰1.6

7.4ā€‰Ā±ā€‰1.7

7.4ā€‰Ā±ā€‰1.5

0.931

ā€ƒHemoglobin (g/dL)

11.9ā€‰Ā±ā€‰3.1

12.2ā€‰Ā±ā€‰1.7

11.7ā€‰Ā±ā€‰4.2

0.517

ā€ƒPhosphate (mg/dL)

3.5ā€‰Ā±ā€‰0.9

3.7ā€‰Ā±ā€‰0.9

3.4ā€‰Ā±ā€‰0.8

0.167

ā€ƒMedian intact-PTH (pg/mL)

120.5 [66.9, 256.6]

133.55 [63.9, 269.2]

120.5 [70.6, 214.1]

0.887

  1. Note: Values for categorical variables are given as number (percentage); values for continuous variables, as meanā€‰Ā±ā€‰standard deviation or median [interquartile range]
  2. Abbreviations: ASA Aspirin, BMI Body Mass Index, DBP Diastolic Blood Pressure, FPG Fasting Plasma Glucose, GFR Glomerular Filtration Rate, HbA1c Hemoglobin A1 C, PTH Parathyroid hormone, RAAS Renin Angiotensin Aldosterone System, SBP Systolic Blood Pressure, UACR Urine Albumin Creatinine Ratio
  3. aA high cardiovascular risk was defined a 10-year cardiovascular diseaseā€‰ā‰„ā€‰10% by Framingham Coronary Heart Disease Risk Score