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Table 1 Patient characteristics by region

From: Mineral and bone disorder management in hemodialysis patients: comparing PTH control practices in Japan with Europe and North America: the Dialysis Outcomes and Practice Patterns Study (DOPPS)

Patient characteristic

Europe

Japan

North America

N patients

5910

2627

18,251

Characteristics at study entry

 Age (years)

65.9 ± 14.7

64.3 ± 12.3

62.7 ± 14.9

 Sex (% male)

62%

66%

55%

 Race (% black)

2%

0%

37%

 Vintage (years)

1.9 (0.4, 5.1)

3.8 (0.7, 9.2)

2.0 (0.5, 4.6)

 Catheter use (%)

26%

1%

32%

 Dialysate calcium (mEq/L)

2.9 ± 0.3

2.8 ± 0.2

2.5 ± 0.2

Mean over 9-month run-in period

 BMI (kg/m2)

26.3 ± 5.5

21.5 ± 3.5

28.7 ± 7.1

 Normalized PCR (g/kg/day)

1.00 ± 0.22

0.93 ± 0.18

0.95 ± 0.22

 Hgb (g/dL)

11.5 ± 1.0

10.6 ± 0.9

11.0 ± 0.9

 Serum creatinine (mg/dL)

7.9 ± 2.4

10.4 ± 2.8

7.9 ± 2.8

 Serum albumin (g/dL)

3.73 ± 0.43

3.71 ± 0.36

3.76 ± 0.38

 Serum calcium (mg/dL)

9.0 ± 0.6

8.9 ± 0.6

9.0 ± 0.6

 Serum phosphorus (mg/dL)

4.9 ± 1.2

5.4 ± 1.0

5.2 ± 1.2

 PTH (pg/mL)*

233 (140, 377)

126 (77, 192)

283 (194, 425)

Slope over 9-month run-in period

 Calcium (mg/dL per year)

0.1 (−0.5, 0.8)

0.1 (− 0.4, 0.7)

0.1 (− 0.5, 0.7)

 Phosphorus (mg/dL per year)

−0.1 (− 1.5, 1.4)

−0.2 (− 1.5, 1.2)

0.1 (− 1.3, 1.5)

 PTH (% change per month)

0.6 (− 6.1, 7.1)

−1.0 (− 7.0, 4.9)

0.5 (− 6.0, 7.1)

MSE over 9-month run-in period**

 Calcium

0.1 (0.1, 0.2)

0.1 (0.1, 0.2)

0.1 (0.1, 0.2)

 Phosphorus

0.6 (0.3, 1.1)

0.5 (0.3, 1.0)

0.7 (0.4, 1.3)

 Log(PTH)

0.1 (0.0, 0.2)

0.1 (0.0, 0.2)

0.1 (0.0, 0.3)

Medications over 9-month run-in period (% any prescription over 9 months)

 Phosphate binder

85%

88%

80%

 Cinacalcet

23%

22%

22%

 IV vitamin D

24%

45%

71%

 Oral vitamin D

51%

45%

26%

 Any active vitamin D

69%

81%

86%

Comorbid conditions (%)

 Coronary artery disease

37%

28%

34%

 Congestive heart failure

20%

19%

30%

 Cerebrovascular disease

16%

13%

11%

 Peripheral vascular disease

31%

15%

15%

 Other cardiovascular disease

31%

24%

19%

 Hypertension

87%

81%

82%

 Diabetes

38%

41%

62%

 Neurologic disease

12%

7%

8%

 Psychiatric disorder

18%

5%

15%

 Lung disease

15%

4%

12%

 Cancer (non-skin)

16%

10%

7%

 Gastrointestinal bleeding

5%

4%

3%

 Recurrent cellulitis, gangrene

9%

3%

9%

  1. Mean ± SD or median (IQR) or % shown
  2. *Geometric mean: Exp(mean(log(PTH)))
  3. **MSE mean squared error from fitted regression model over 9-month run-in period