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Table 4 Association between PTH slope/residuals/mean and mortality, by vintage

From: Mineral and bone disorder management in hemodialysis patients: comparing PTH control practices in Japan with Europe and North America: the Dialysis Outcomes and Practice Patterns Study (DOPPS)

Exposure

Vintage < 90 days

Vintage 90 days - 1 year

Vintage > 1 year

N (%)

Adjusted*

HR (95% CI)

N (%)

Adjusted*

HR (95% CI)

N (%)

Adjusted*

HR (95% CI)

PTH slope (% change per month)

 Decreased > 15%

459 (12%)

1.06 (0.74–1.52)

445 (9%)

1.12 (0.83–1.52)

1189 (7%)

1.16 (1.00–1.35)

 Decreased 5–15%

935 (24%)

1.06 (0.81–1.38)

1075 (21%)

0.92 (0.75–1.14)

3267 (19%)

1.13 (1.03–1.24)

 No change ±5%

1373 (35%)

1 (Ref.)

1949 (38%)

1 (Ref.)

7082 (42%)

1 (Ref.)

 Increased 5–15%

766 (20%)

1.20 (0.91–1.58)

1095 (22%)

0.94 (0.77–1.14)

3689 (22%)

1.06 (0.97–1.17)

 Increased > 15%

374 (10%)

1.34 (0.99–1.82)

527 (10%)

0.79 (0.60–1.06)

1612 (10%)

1.15 (1.01–1.31)

PTH mean squared residuals

  < 0.01

386 (10%)

1.09 (0.79–1.51)

589 (12%)

1.23 (0.96–1.56)

1936 (12%)

0.98 (0.86–1.12)

 0.01–0.05

844 (22%)

0.78 (0.59–1.03)

1214 (24%)

0.97 (0.81–1.16)

3964 (24%)

0.96 (0.87–1.06)

 0.05–0.20

1358 (35%)

1 (Ref.)

1757 (35%)

1 (Ref.)

5981 (36%)

1 (Ref.)

 0.20–0.50

793 (20%)

0.83 (0.64–1.08)

950 (19%)

0.91 (0.74–1.11)

3081 (18%)

1.07 (0.97–1.19)

  > 0.50

526 (13%)

0.77 (0.57–1.05)

581 (11%)

0.88 (0.66–1.17)

1877 (11%)

1.05 (0.92–1.19)

PTH geometric mean (pg/mL)

  < 100

482 (12%)

1.10 (0.81–1.49)

739 (15%)

0.93 (0.75–1.16)

1658 (10%)

1.07 (0.94–1.22)

 100–199

1114 (29%)

0.92 (0.74–1.15)

1421 (28%)

0.93 (0.78–1.10)

3663 (22%)

0.96 (0.87–1.05)

 200–399

1581 (40%)

1 (Ref.)

2034 (40%)

1 (Ref.)

6838 (41%)

1 (Ref.)

 400–599

470 (12%)

0.82 (0.56–1.20)

554 (11%)

1.15 (0.89–1.49)

2511 (15%)

1.13 (1.01–1.26)

  ≥ 600

260 (7%)

1.13 (0.73–1.77)

343 (7%)

1.00 (0.74–1.36)

2169 (13%)

1.44 (1.26–1.65)

  1. *Adjusted as in Table 2, Model