Table 2 Criteria for withdrawal, reduction, and discontinuation of lenvatinib

Hypertension

Systolic pressure ≥ 140 mmHg and diastolic pressure ≥ 90 mmHg

Continue using lenvatinib in combination with antihypertensive agents

Systolic pressure ≥ 160 mmHg and diastolic pressure ≥ 100 mmHg despite antihypertensive treatment

Withdraw until systolic pressure ≤ 150 mmHg or diastolic pressure ≤ 95 mmHg is achieved, followed by use of antihypertensive agents and resumption of lenvatinib treatment with a 1-stage reduction in dosage

Side effects (grade 4)

Discontinuation of lenvatinib

Other side effects

Side effects (grade 2 or 3)

Withdraw lenvatinib until baseline status is regained or the condition is ameliorated to grade ≤ 1. If resumed, then lenvatinib should be administered with a 1-stage reduction in dosage

Side effects (grade 4)

Discontinuation of lenvatinib