Table 1 Clinical, biological and demographic characteristics
From: TINU-associated Fanconi syndrome: a case report and review of literature
Autor (year) | Age/sex | Origin | Initial presentation | Uveitis type | Serum creatinine (mg/dl) | Serum potassium (mmol/l) | Serum phosphate (mmol/l) | Serum uric acid (mg/dl) | Serum bicarbonate (mEq/l) | Other manifestation | Other renal manifestations | Steroid therapy | Predisposing factor (?) | Renal outcome | Uveitis relapse |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Takeda (1988) [12] | 45/F | Japan | NA | Bilateral iritis | 1,8 | 4 | 0,94 | 1,8 | 17 | NA | Metabolic acidosis, glucosuria, AA | topical | Unknown | NA | NA |
Lessard (1989) [13] | 48/F | White (USA) | Uveitis | Left anterior uveitis | 2,5 | 2,9 | 0,55 | NA | 20 | anorexia, malaise, fatigue, nausea, headache, chills | u pH 6,5, glucosuria, proteinuria, AA, urinary eosinophilia | topical steroids, oral prednisone (60 mg/d, 4w; gradual tapering for 16w) | Oral penicillin for toothache? High ASLO titer | Favorable, persistent hypophosphatemia | NA |
Igarashi (1992) [14] | 11/M | Japan | TIN | Bilateral anterior uveitis | 1,2 | 3,5 | 1,16 | 1,3 | 16,3 | malaise, asthenia, weight loss | u pH 7,36, metabolic acidosis, distal tubular dysfunction, glucosuria, proteinuria, AA | topical steroids | Unknown | Favorable, normal creat. (13 months), normalization of tubular function | NA |
Wakaki (2001) [9] | 13/F | Japan | Uveitis | Bilateral anterior uveitis | 1,1 | 3,3 | 0,83 | 1,8 | 25 | fatigue, abdominal pain, weight loss | u pH 7.5, distal tubular dysfunction, glucosuria, proteinuria, leucocyturia, urinary eosinophils | topical steroids | Auto-antibody to renal tubular cells | Favorable, creat. 0,6 (6 months), normalization of tubular function | NA |
Koike (2006) [4] | 32/F | Japan | TIN | Bilateral iritis | 3,39 | 3,2 | 0,9 | 2,8 | 19,4 | fatigue, anorexia, weight loss, fever | u pH 6.5, metabolic acidosis, microscopic hematuria, glucosuria, proteinuria, AA, leucocyturia | topical steroids, oral prednisolone (0.8 mg/kg/d) | levofloxacin for fever, possible streptococcal infection (ASLO +) | Favorable, creat. 0,59 (36 weeks), persistent mild hypokalemia | Yes (5 months) |
Yao (2009) [15] | 57/F | Taiwan | Uveitis | Bilateral anterior uveitis | 1,95 | 3 | 0,8 | 2,2 | 15,7 | NA | Metabolic acidosis, glucosuria, proteinuria | Oral methylpred. (16 mg/d) | NSAID for herpes zoster infection | Favorable, creat. 1,39 (20 days), persistent glucosuria | NA |
Llorente (2012) [16] | 9/M | Spain | TIN | Anterior uveitis | 1,2 | 4,3 | 1,4 | 2,1 | 17,5 | fatigue, anorexia, weight loss, fever, enuresis, hypertension | Metabolic acidosis, glucosuria, proteinuria, leucocyturia | topical steroids | Unknown, high ASLO titer | Favorable, creat. 0,7 (30 weeks), persistent metabolic acidosis | Yes |
Legendre (2016) [6] | 23/F | NA | NA | NA | 1,71 | NA | NA | NA | NA | NA | NA | 1 mg/kg/d | NA | Favorable, creat 1.15 (30 months) | NA |
Legendre (2016) [6] | 46/F | NA | NA | NA | 1,78 | NA | NA | NA | NA | NA | NA | 0.5 mg/kg/d | NA | Favorable, creat 0.6 (30 months) | NA |
Present case | 55/F | Morocco | TIN | Bilateral anterior uveitis | 1,14 | 3,47 | 0,57 | 1,9 | 25 | None | u pH 7, glucosuria, AA, proteinuria, leucocyturia | topical steroids, methylpred. (48 mg/d) | Unknown | Favorable, creat. 0,89 (6 weeks), persistent leucocyturia | Yes (1 month; before oral steroids treatment) |