A. Nephrotic syndrome | The presence of a urine protein-to-creatinine ratio of 1.8 or above and serum albumin of 2.5Â g/dL or below. |
B. Complicated nephrotic syndrome | A patient that fulfills any of the following criteria is deemed to suffer from complicated nephrotic syndrome: (1) Diagnosed with frequent relapse or steroid dependence and once again diagnosed with frequent relapse or steroid dependence after completion of immunosuppressive drug therapy (cyclosporine, cyclophosphamide, mizoribine, etc.) (2) Diagnosed with frequent relapse or steroid dependence and once again diagnosed with frequent relapse or steroid dependence during immunosuppressive drug therapy (cyclosporine, cyclophosphamide, mizoribine, etc.) (3) Diagnosed with steroid resistance and diagnosed with frequent relapse or steroid dependence during or after the completion of immunosuppressive drug therapy (cyclosporine or combination of cyclosporine and methylprednisolone, etc.) |
C. Remission | Negative protein on urine dipstick in the first morning urine for 3 consecutive days. |
D. Steroid sensitivity | When the daily administration of prednisolone at 60Â mg/m2/day leads to remission within 4Â weeks. |
E. Relapse | Protein 2+ or above detected by urine dipstick in the first morning urine for 3 consecutive days and prednisolone treatment is required. |
F. Frequent relapse | Two or more relapses within 6Â months after initial remission or 4 or more relapses within any 12-month period. |
G. Steroid dependence | Two consecutive relapses during the reduction of steroid therapy or within 2Â weeks of discontinuation of steroid therapy. |
H. Steroid resistance | When the daily administration of prednisolone at 60Â mg/m2/day does not lead to remission within 4Â weeks. |