Table 1 Baseline demographic and clinical data
Age (years) | 72.7 [68.5–76.8] |
Female | 72 (48) |
Comorbidities | |
 Hypertension | 99 (66) |
 Diabetes mellitus | 18 (12) |
 Cardiovascular diseases | 21 (14) |
 Malignancy | 16 (11) |
 Charlson Comorbidity Index | 4 [3–5] |
Performance Status | |
 0–2 | 129 (87) |
 3–4 | 20 (13) |
AAV type | |
 MPO/PR3 | 101/46 |
 GPA | 60 (40) |
 MPA | 80 (54) |
 RVL | 9 (6) |
Renal involvement | |
 Peak SCr (μmol/l) | 337 [221–522] |
 uPCR (g/day) | 1.8 [0.9–2.6] |
 Dialysis | 45 (30) |
Renal biopsy | 131 (88) |
 Focal | 31 |
 Crescentic | 38 |
 Mixed | 36 |
 Sclerotic | 26 |
Inflammatory parameters | |
 C-reactive protein (mg/l) | 88 [19–151] |
 Serum albumin (g/l) | 28 [22–32] |
 Leukocyte count (× 109/l) | 9.2 [7.1–12.9] |
 Haemoglobin (g/dl) | 9.4 [8.3–10.5] |
Organ involvement | |
 Cutaneous | 12 (8) |
 Ocular | 8 (5.3) |
 Ear, nose, throat | 27 (18) |
 Pulmonary | 67 (45) |
 Cardiac | 8 (5.3) |
 Gastrointestinal | 11 (7.3) |
 Musculoskeletal | 41 (27.5) |
 Nervous system | 27 (18) |
BVAS | 18 [14–22] |
Five-Factor Score ≥ 3 | 120 (81) |