Fig. 1

a Although there were no major abnormalities in the glomeruli (left-upper panel), the leakage of red blood cells into the Bowman’s space was observed (Masson Trichrome staining; the inset of left-upper panel). An electron micrograph showed the leakage of red blood cells, two of which were dysmorphic, into Bowman’s space (right-upper panel). Tubulointerstitial fibrosis with acute tubular necrosis was detected (Masson Trichrome staining; lower panel). b Massive erythrocyte cast formation was observed in the tubular lumen and the inset denoted red blood cells in Hematoxylin and eosin staining. Scale bars, 50 μm