| |
α1m
|
β2-m
|
IL-18
|
KIM-1
|
TFF3
|
Clusterin
|
NGAL
|
MCP-1
|
EGF
|
UMOD
|
ACR
|
CysC
|
OPN
|
YKL-40
|
|---|
|
Risk Factors
|
% Estimate (95% CI)
|
% Estimate (95% CI)
|
% Estimate (95% CI)
|
% Estimate (95% CI)
|
% Estimate (95% CI)
|
% Estimate (95% CI)
|
% Estimate (95% CI)
|
% Estimate (95% CI)
|
% Estimate (95% CI)
|
% Estimate (95% CI)
|
% Estimate (95% CI)
|
% Estimate (95% CI)
|
% Estimate (95% CI)
|
% Estimate (95% CI)
|
|
Age (per decade)
|
36 (21, 52)
|
11 (−10, 37)
|
10 (−1, 22)
|
42 (27, 58)
|
9 (−15, 39)
|
30 (16, 47)
|
21 (4, 40)
|
26 (16, 35)
|
−14 (−19, −7)
|
−21 (−30, − 11)
|
23 (6, 42)
|
3 (−4, 11)
|
5 (−4, 15)
|
18 (2, 37)
|
|
Black Race
|
16 (−10, 49)
|
131 (39, 284)
|
31 (3, 68)
|
− 25 (−44, 0.7)
|
170 (60, 358)
|
− 7 (− 33, 28)
|
102 (44, 181)
|
9 (− 12, 36)
|
− 25 (− 37, − 10.8)
|
−8 (− 34, 29)
|
37 (−0.6, 90)
|
3 (− 14, 23)
|
−9 (− 25, 10)
|
61 (15, 124)
|
|
Current smoking
|
106 (61, 164)
|
57 (− 4, 156)
|
38 (9, 75)
|
5 (− 19, 35)
|
59 (− 7, 17)
|
50 (11, 102)
|
29 (− 11, 86)
|
8 (−13, 35)
|
−4 (− 19, 14)
|
−2 (− 26, 30)
|
39 (− 4, 101)
|
18 (0.13, 39)
|
−12 (− 28, 9)
|
4 (−26, 47)
|
|
Diabetes
|
29 (− 1, 68)
|
−54 (− 76, − 10)
|
38 (8, 76)
|
27 (− 2, 65)
|
−28 (−64, 44)
|
28 (−6, 75)
|
52 (1.6, 126)
|
16 (− 8, 47)
|
−20 (− 34, − 3)
|
− 33 (− 49, − 11)
|
39 (− 9, 114)
|
− 14 (− 31, 8)
|
6 (− 15, 32)
|
3 (− 34, 61)
|
|
Hypertension
|
20 (−2, 47)
|
5 (−31, 59)
|
6 (− 14, 30)
|
14 (− 8, 42)
|
16 (− 26, 83)
|
11 (− 13, 43)
|
4 (−23, 41)
|
3 (− 14, 23)
|
−24 (− 34, − 13)
|
4 (− 17, 31)
|
56 (16, 111)
|
−2 (− 14, 11)
|
− 4 (− 19, 14)
|
21 (− 11, 65)
|
|
HCV-seropositive
|
62 (25, 111)
|
107 (25, 245)
|
56 (17, 107)
|
29 (−4.0, 72)
|
139 (27, 351)
|
33 (−4.0, 84)
|
34 (− 6, 90)
|
3 (− 21, 35)
|
−21 (− 36, − 49)
|
−8 (− 30, 22)
|
−28 (− 64, 44)
|
12.5 (− 7, 36)
|
−4 (− 299, 29)
|
39 (− 1.6, 97)
|
|
HIV RNA (per 10-fold higher)
|
4 (− 4, 11)
|
26 (9, 45)
|
18 (10, 27)
|
4 (−5, 13)
|
6 (−10, 23)
|
− 4 (− 13, 6)
|
0.7 (− 9, 12)
|
3 (− 4, 9)
|
− 0.7 (− 5, 49)
|
6 (− 2, 15)
|
7 (−3, 19)
|
6 (2, 11)
|
− 0.8 (− 7, 6)
|
9 (− 2, 21)
|
|
CD4+ count (per (doubling)
|
−12 (− 22, − 1)
|
−35 (− 49, − 18)
|
− 21 (− 30, − 11)
|
−7 (− 17, 4)
|
−3 (− 26, 29)
|
−0.4 (− 15, 16)
|
2 (−16, 24)
|
− 15 (− 24, − 5)
|
2 (− 5, 10)
|
−2 (− 14, 12)
|
−11.0 (− 24, 4)
|
− 9 (−17, −1)
|
0.9 (− 9, 12)
|
−15 (− 30, 1.4)
|
- Estimates from linear regression models adjusted for urine creatinine. α1m α1-microglobulin, β2m β2-microglobulin, IL-18 interleukin 18, KIM-1 kidney injury marker-1, TFF3 trefoil factor 3, NGAL neutrophil gelatinase-associated lipocalin, MCP-1 monocyte chemoattractant protein-1, EGF epidermal growth factor, UMOD uromodulin, ACR albumin-to-creatinine ratio, CysC cystatin C, OPN osteopontin, YKL-40 chitinase-3-like protein-1
