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Table 2 Baseline histological features

From: The effects of add-on corticosteroids on renal outcomes in patients with biopsy proven HIV associated nephropathy: a single centre study from South Africa

Histological features Total (%) ART + C (%) ART Alone (%) P Valuea
N = 38 N = 21 N = 17  
Classic HIVAN 68.4% 66.7% 70.6% 0.791
FSGS [NOS] with tubulointerstitial inflammation and microcysts 26.3% 33.3% 17.6% 0.268
Podocytopathy with tubulointerstitial inflammation and microcysts 5.3% 0% 11.8% 0.103
Interstitial disease
 Lymphocytic infiltration[grading]
  0 5.3% 4.8% 5.9% 0.799
  1 34.2% 8.6% 41.2%
  2 26.3% 23.8% 29.4%
  3 21.1% 28.6% 11.8%
  4 13.2% 14.3% 11.8%
 Plasmacytic infiltration[grading]
  0 5.3% 4.8% 5.9% 0.533
  1 28.9% 28.6% 29.4%
  2 18% 9.5% 29.4%
  3 13.2% 19.0% 5.9%
  4 34.2% 38.1% 29.4%
 Interstitial fibrosis [grading]
  0 5.3% 0% 11.8% 0.389
  1 28.9% 14.3% 35.3%
  2 15.8% 14.3% 11.8%
  3 36.8% 23.8% 29.4%
  4 13.1% 4.8% 11.8%
 Microcysts [grading]
  0 31.6% 23.8% 41.2% 0.698
  1 28.9% 33.3% 23.5%
  2 28.9% 33.3% 23.5%
  3 10.5% 9.5% 11.8%
  4
  1. ART + C Antiretrovirals + corticosteroids, ART Alone Antiretrovirals alone, FSGS Focal segmental glomerulosclerosis, NOS Not otherwise specified
  2. Microcysts, lymphocytic infiltrate and fibrosis in the interstitium was graded 0–4: [0 < 5%; 1 = 5–25%; 2 = 26–50%; 3 = 51–75%;4 > 75%] The percentage of plasma cells within the lymphocytic infiltrate was graded [0 = 0; 1 < 5%; 2 = 6–15%; 3 = 16–30% and 4 > 30%]
  3. Podocytes and parietal cell hypertrophy/hyperplasia were graded 0 = absent; 1 = present
  4. a = the Fisher’s exact test used to compare baseline histological features between groups