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Table 2 Baseline histological features

From: The effects of add-on corticosteroids on renal outcomes in patients with biopsy proven HIV associated nephropathy: a single centre study from South Africa

Histological features

Total (%)

ART + C (%)

ART Alone (%)

P Valuea

N = 38

N = 21

N = 17

 

Classic HIVAN

68.4%

66.7%

70.6%

0.791

FSGS [NOS] with tubulointerstitial inflammation and microcysts

26.3%

33.3%

17.6%

0.268

Podocytopathy with tubulointerstitial inflammation and microcysts

5.3%

0%

11.8%

0.103

Interstitial disease

 Lymphocytic infiltration[grading]

  0

5.3%

4.8%

5.9%

0.799

  1

34.2%

8.6%

41.2%

  2

26.3%

23.8%

29.4%

  3

21.1%

28.6%

11.8%

  4

13.2%

14.3%

11.8%

 Plasmacytic infiltration[grading]

  0

5.3%

4.8%

5.9%

0.533

  1

28.9%

28.6%

29.4%

  2

18%

9.5%

29.4%

  3

13.2%

19.0%

5.9%

  4

34.2%

38.1%

29.4%

 Interstitial fibrosis [grading]

  0

5.3%

0%

11.8%

0.389

  1

28.9%

14.3%

35.3%

  2

15.8%

14.3%

11.8%

  3

36.8%

23.8%

29.4%

  4

13.1%

4.8%

11.8%

 Microcysts [grading]

  0

31.6%

23.8%

41.2%

0.698

  1

28.9%

33.3%

23.5%

  2

28.9%

33.3%

23.5%

  3

10.5%

9.5%

11.8%

  4

  1. ART + C Antiretrovirals + corticosteroids, ART Alone Antiretrovirals alone, FSGS Focal segmental glomerulosclerosis, NOS Not otherwise specified
  2. Microcysts, lymphocytic infiltrate and fibrosis in the interstitium was graded 0–4: [0 < 5%; 1 = 5–25%; 2 = 26–50%; 3 = 51–75%;4 > 75%] The percentage of plasma cells within the lymphocytic infiltrate was graded [0 = 0; 1 < 5%; 2 = 6–15%; 3 = 16–30% and 4 > 30%]
  3. Podocytes and parietal cell hypertrophy/hyperplasia were graded 0 = absent; 1 = present
  4. a = the Fisher’s exact test used to compare baseline histological features between groups