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Table 3 Comparison of metabolic parameters at the beginning and at the end of follow up for kidney donors, matched-controls and healthy control group

From: Long term metabolic and renal outcomes of kidney donors compared to controls with excellent kidney function

Variable Time Donors Matched-controls Healthy controls P value
211 211 2534
BMI, kg/m2 Baseline 25.64 ± 3.4a 25.3 ± 3.3a 25 ± 2.7b 0.003
LDFU 26.3 ± 4.19a 25.8 ± 3.8a 24.6 ± 3.7b < 0.001
Delta BMI + 0.65 ± 1.4a + 0.41 ± 1.9a −0.3 ± 2.7b < 0.001
HDL, mg/dl Baseline 51.3 ± 10.2b 58.1 ± 14a 55.8 ± 14a < 0.001
LDFU 54.4 ± 13.1b 57.3 ± 14.2a 55 ± 14.5a < 0.001
Delta HDL + 3.1 ± 13.8b − 0.7 ± 9.3a − 0.6 ± 9.3a < 0.001
LDL, mg/dl Baseline 109.8 ± 23.2b 117.3 ± 32.9a 121.6 ± 30a < 0.001
LDFU 110.5 ± 28.4 111.1 ± 29.6 112.9 ± 27.4 0.340
Delta LDL + 0.73 ± 22.2 − 5.9 ± 26.9a −7.9 ± 28.6a < 0.001
TG, mg/dl Baseline 111.1 ± 42.4a 99.3 ± 57b 108.9 ± 62.4a 0.025
LDFU 117.1 ± 66.7b 102.2 ± 62.4a 106.9 ± 60.3a 0.011
Delta TG 15.9 ± 51.5b 5.1 ± 59.5a 3.96 ± 63.4a 0.019
SBP, mmHg Baseline 121.6 ± 11.5a 117.4 ± 13.3b 119.6 ± 13.7a 0.008
LDFU 126.6 ± 12.6b 122.2 ± 14.6a 123.1 ± 14.8a 0.002
Delta SBP 5.1 ± 12 4.8 ± 11.7 3.7 ± 13.9 0.214
DBP, mmHg Baseline 74.2 ± 8a 73.9 ± 7.1a 75.5 ± 7.8b 0.001
LDFU 76.6 ± 7.9 75.4 ± 8.6 76.9 ± 9.3 0.082
Delta DBP 2.4 ± 8.5 1.55 ± 8.1 1.29 ± 9.5 0.255
HbA1C, % Baseline 5.3 ± 0.43b 5.26 ± 0.4a 5.23 ± 0.4b 0.002
LDFU 5.52 ± 0.5 5.5 ± 0.9 5.45 ± 0.46a 0.006
Delta A1C 0.16 ± 0.5 0.19 ± 0.34 0.18 ± 0.26 0.760
Hypertension, % Baseline 10.9 10.7 12.8 0.491
New onset 11.8 7.9 10.6 0.311
Metabolic syndrome, % Baseline 5.2 3.8 3.3 0.216
New onset 21.9 13.1 15.1 0.032
Diabetes mellitus, % Baseline 0 0 0 1
New onset 5.8 3.3 2.5 0.019
MACE, % LDFU 1.9 0.5 4.9 < 0.001
  1. BMI body mass index, DBP diastolic blood pressure, HDL high density, lipoprotein, LDFU last day of follow up, LDL low density lipoprotein, MACE major adverse cardiovascular events, SBP systolic blood pressure, TG triglycerides, UACR urine albumin to creatinine ratio
  2. letters annotation mark significant difference between groups in post hoc analysis