Insulin resistance and chronic kidney disease progression, cardiovascular events, and death: findings from the chronic renal insufficiency cohort study

Table 2 Multivariable-adjusted association of HOMA-IR and factors previously reported to be associated with insulin resistance -- Chronic Renal Insufficiency Cohort (CRIC) Study participants without diabetes at baseline (N = 1806)

Demographic/Clinical variables	β	P
Age, years	0.005	0.001
Non-smoking	0.13	0.002
Systolic blood pressure, mmHg	−0.001	0.28
Physical activity^a	− 0.0001	0.43
Anthropometric Variables
Body mass index, kg/m²	0.02	< 0.001
Waist circumference, cm	0.01	< 0.001
Fat-free mass, kg	−0.003	0.15
Medication Use
No ACEi or ARB use	−0.05	0.11
Laboratory Values
eGFR, mL/min/1.73m²	−0.00001	0.99
Hemoglobin, mmol/L	0.04	< 0.001
LDL, mmol/L	−0.002	< 0.001
HDL, mmol/L	−0.003	0.001
(log) Triglycerides, mmol/L	0.30	< 0.001
(log) High-sensitivity CRP, nmol/L	0.04	0.03

^aPhysical activity measured as total reported METS in one week
Model also adjusted for sex, race, ethnicity, and education
HOMA-IR – homeostasis model assessment insulin resistance, ACEi- angiotensin-converting enzyme inhibitor, ARB – angiotensin receptor blocker, eGFR – estimated glomerular filtration rate, LDL – low density lipoprotein, HDL – high density lipoprotein, CRP – C-reactive protein

ISSN: 1471-2369