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Table 2 Multivariable-adjusted association of HOMA-IR and factors previously reported to be associated with insulin resistance -- Chronic Renal Insufficiency Cohort (CRIC) Study participants without diabetes at baseline (N = 1806)

From: Insulin resistance and chronic kidney disease progression, cardiovascular events, and death: findings from the chronic renal insufficiency cohort study

Demographic/Clinical variables β P
 Age, years 0.005 0.001
 Non-smoking 0.13 0.002
 Systolic blood pressure, mmHg −0.001 0.28
 Physical activitya − 0.0001 0.43
Anthropometric Variables
 Body mass index, kg/m2 0.02 < 0.001
 Waist circumference, cm 0.01 < 0.001
 Fat-free mass, kg −0.003 0.15
Medication Use
 No ACEi or ARB use −0.05 0.11
Laboratory Values
 eGFR, mL/min/1.73m2 −0.00001 0.99
 Hemoglobin, mmol/L 0.04 < 0.001
 LDL, mmol/L −0.002 < 0.001
 HDL, mmol/L −0.003 0.001
  (log) Triglycerides, mmol/L 0.30 < 0.001
  (log) High-sensitivity CRP, nmol/L 0.04 0.03
  1. aPhysical activity measured as total reported METS in one week
  2. Model also adjusted for sex, race, ethnicity, and education
  3. HOMA-IR – homeostasis model assessment insulin resistance, ACEi- angiotensin-converting enzyme inhibitor, ARB – angiotensin receptor blocker, eGFR – estimated glomerular filtration rate, LDL – low density lipoprotein, HDL – high density lipoprotein, CRP – C-reactive protein