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Table 2 Factors associated with infection at 3 months on univariable and multivariable proportional hazards analysis

From: Intravenous pulse methylprednisolone for induction of remission in severe ANCA associated Vasculitis: a multi-center retrospective cohort study

 

Univariable

Multivariable

 

HR (95% CI)

p value

HR (95% CI)

p value

(A) Time to infection at 3 months

 Treatment with MP

2.2 (1.1–4.2)

0.018

2.7 (1.4–5.3)

0.004

 Leukopenia preceding infection

3.6 (1.6–8.0)

0.001

4.3 (1.9–9.5)

< 0.001

 Dose of oral prednisolone, g

5.4 (1.1–27.3)

0.043

8.5 (1.4–53.2)

0.022

(B) Time to severe infection at 3 months

 Treatment with MP

2.1 (1.0–4.3)

0.043

2.9 (1.3–6.6)

0.010

 Leukopenia preceding infection

4.8 (2.1–10.9)

<  0.001

5.6 (2.4–13.0)

<  0.001

 Dose of oral prednisolone, g

9.2 (1.5–54.7)

0.015

17.9 (1.9–164.5)

0.011

 BVAS score

1.1 (1.0–1.2)

0.005

1.1 (1.0–1.2)

0.131

 Lung involvement

1.9 (0.9–3.9)

0.096

1.2 (0.5–3.1)

0.678

  1. Dose of oral prednisolone was entered as a segmented time dependent variable as follows: dose at 1 week, 2 weeks, 1 month and 3 months
  2. HR = hazard ratio, CI = confidence intervals