Intravenous pulse methylprednisolone for induction of remission in severe ANCA associated Vasculitis: a multi-center retrospective cohort study

Table 3 Multivariable proportional hazards model for survival at 12 months

	Hazard ratio (95% Confidence Interval)	P value
Age, years	1.07 (1.03–1.12)	0.001
Infection by 3 months	5.58 (1.99–15.65)	0.001
Lung involvement	3.53 (1.21–10.31)	0.021
Cyclophosphamide dose, g	0.93 (0.69–1.26)	0.648
Treatment with MP	0.75 (0.28–2.01)	0.564

Dose of cyclophosphamide was entered in the model as a segmented time dependent covariate as follows: dose at 2 weeks, 1 month, 3 months, 6 months and 12 months
Infection during the first 3 months was added as a time dependent covariate indicating whether such an infection had occurred

ISSN: 1471-2369