Table 2 Plasma metabolites significantly (p < 0.05) associated with baseline eGFR. Effect size represents the magnitude and direction (+/−) of association between a given metabolite and eGFR, estimated by linear regression, while controlling for the selected HALT covariates, age, sex, genotype, site of sample collection, and BMI. KEGG ID is the metabolite identifier for Kyoto Encyclopedia of Genes and Genomes (KEGG) and PubChem ID is for the chemical molecule database maintained by the National Center for Biotechnology Information
Metabolite | Effect Size (SD) | p-value | FDR q-value | KEGG ID | PubChem ID |
|---|---|---|---|---|---|
pseudo uridine | −0.1796 (0.023) | < 0.0001 | < 0.0001 | C02067 | 15,047 |
indole-3-lactate | −0.1204 (0.021) | < 0.0001 | < 0.0001 | C02043 | 92,904 |
creatinine | −0.0616 (0.016) | 0.0002 | 0.0040 | C00791 | 588 |
isothreonic acid | −0.0616 (0.017) | 0.0004 | 0.0076 | C21649 | 151,152 |
uric acid | −0.0508 (0.016) | 0.0016 | 0.0249 | C00366 | 1175 |
beta-alanine | −0.0369 (0.012) | 0.0027 | 0.0349 | C00099 | 239 |
isothreitol | −0.0504 (0.017) | 0.0034 | 0.0369 | C16884 | 169,019 |
Arabitol | −0.0431 (0.015) | 0.0038 | 0.0369 | C01904 | 94,154 |
ribonic acid | −0.0577 (0.020) | 0.0049 | 0.0410 | C01685 | 5,460,677 |
indole-3-acetate | −0.0450 (0.016) | 0.0061 | 0.0410 | C00954 | 802 |
citric acid | −0.0685 (0.025) | 0.0063 | 0.0410 | C00158 | 311 |
L-gulonic acid | −0.0605 (0.022) | 0.0063 | 0.0410 | C00800 | 6,857,417 |
salicylic acid | −0.0166 (0.006) | 0.0092 | 0.0532 | C00805 | 338 |
myo-inositol | −0.0421 (0.016) | 0.0096 | 0.0532 | C00137 | 892 |
trans-4-hydroxyproline | −0.0428 (0.017) | 0.0115 | 0.0595 | C01157 | 5810 |
Sucrose | −0.0210 (0.009) | 0.0237 | 0.1148 | C00089 | 5988 |
2,3-dihydroxybutanoic acid NIST | −0.0364 (0.017) | 0.0294 | 0.1269 |  | 250,402 |
Glycine | −0.0492 (0.022) | 0.0295 | 0.1269 | C00037 | 750 |
levoglucosan | −0.0176 (0.008) | 0.0342 | 0.1396 |  | 2,724,705 |
Lyxitol | −0.0244 (0.012) | 0.0463 | 0.1796 | C00532 | 439,255 |