Plasma metabolites and lipids associate with kidney function and kidney volume in hypertensive ADPKD patients early in the disease course

Table 2 Plasma metabolites significantly (p < 0.05) associated with baseline eGFR. Effect size represents the magnitude and direction (+/−) of association between a given metabolite and eGFR, estimated by linear regression, while controlling for the selected HALT covariates, age, sex, genotype, site of sample collection, and BMI. KEGG ID is the metabolite identifier for Kyoto Encyclopedia of Genes and Genomes (KEGG) and PubChem ID is for the chemical molecule database maintained by the National Center for Biotechnology Information

Metabolite	Effect Size (SD)	p-value	FDR q-value	KEGG ID	PubChem ID
pseudo uridine	−0.1796 (0.023)	< 0.0001	*< 0.0001*	C02067	15,047
indole-3-lactate	−0.1204 (0.021)	< 0.0001	*< 0.0001*	C02043	92,904
creatinine	−0.0616 (0.016)	0.0002	*0.0040*	C00791	588
isothreonic acid	−0.0616 (0.017)	0.0004	*0.0076*	C21649	151,152
uric acid	−0.0508 (0.016)	0.0016	*0.0249*	C00366	1175
beta-alanine	−0.0369 (0.012)	0.0027	*0.0349*	C00099	239
isothreitol	−0.0504 (0.017)	0.0034	*0.0369*	C16884	169,019
Arabitol	−0.0431 (0.015)	0.0038	*0.0369*	C01904	94,154
ribonic acid	−0.0577 (0.020)	0.0049	*0.0410*	C01685	5,460,677
indole-3-acetate	−0.0450 (0.016)	0.0061	*0.0410*	C00954	802
citric acid	−0.0685 (0.025)	0.0063	*0.0410*	C00158	311
L-gulonic acid	−0.0605 (0.022)	0.0063	*0.0410*	C00800	6,857,417
salicylic acid	−0.0166 (0.006)	0.0092	0.0532	C00805	338
myo-inositol	−0.0421 (0.016)	0.0096	0.0532	C00137	892
trans-4-hydroxyproline	−0.0428 (0.017)	0.0115	0.0595	C01157	5810
Sucrose	−0.0210 (0.009)	0.0237	0.1148	C00089	5988
2,3-dihydroxybutanoic acid NIST	−0.0364 (0.017)	0.0294	0.1269		250,402
Glycine	−0.0492 (0.022)	0.0295	0.1269	C00037	750
levoglucosan	−0.0176 (0.008)	0.0342	0.1396		2,724,705
Lyxitol	−0.0244 (0.012)	0.0463	0.1796	C00532	439,255

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