Skip to main content

Table 2 Plasma metabolites significantly (p < 0.05) associated with baseline eGFR. Effect size represents the magnitude and direction (+/−) of association between a given metabolite and eGFR, estimated by linear regression, while controlling for the selected HALT covariates, age, sex, genotype, site of sample collection, and BMI. KEGG ID is the metabolite identifier for Kyoto Encyclopedia of Genes and Genomes (KEGG) and PubChem ID is for the chemical molecule database maintained by the National Center for Biotechnology Information

From: Plasma metabolites and lipids associate with kidney function and kidney volume in hypertensive ADPKD patients early in the disease course

Metabolite Effect Size (SD) p-value FDR q-value KEGG ID PubChem ID
pseudo uridine −0.1796 (0.023) < 0.0001 < 0.0001 C02067 15,047
indole-3-lactate −0.1204 (0.021) < 0.0001 < 0.0001 C02043 92,904
creatinine −0.0616 (0.016) 0.0002 0.0040 C00791 588
isothreonic acid −0.0616 (0.017) 0.0004 0.0076 C21649 151,152
uric acid −0.0508 (0.016) 0.0016 0.0249 C00366 1175
beta-alanine −0.0369 (0.012) 0.0027 0.0349 C00099 239
isothreitol −0.0504 (0.017) 0.0034 0.0369 C16884 169,019
Arabitol −0.0431 (0.015) 0.0038 0.0369 C01904 94,154
ribonic acid −0.0577 (0.020) 0.0049 0.0410 C01685 5,460,677
indole-3-acetate −0.0450 (0.016) 0.0061 0.0410 C00954 802
citric acid −0.0685 (0.025) 0.0063 0.0410 C00158 311
L-gulonic acid −0.0605 (0.022) 0.0063 0.0410 C00800 6,857,417
salicylic acid −0.0166 (0.006) 0.0092 0.0532 C00805 338
myo-inositol −0.0421 (0.016) 0.0096 0.0532 C00137 892
trans-4-hydroxyproline −0.0428 (0.017) 0.0115 0.0595 C01157 5810
Sucrose −0.0210 (0.009) 0.0237 0.1148 C00089 5988
2,3-dihydroxybutanoic acid NIST −0.0364 (0.017) 0.0294 0.1269   250,402
Glycine −0.0492 (0.022) 0.0295 0.1269 C00037 750
levoglucosan −0.0176 (0.008) 0.0342 0.1396   2,724,705
Lyxitol −0.0244 (0.012) 0.0463 0.1796 C00532 439,255
  1. bold Q-values indicate signficance, <0.05