Fig. 1

Box plots showing the postoperative course of the absolute (a/c/e/g/i) and relative (b/d/f/h/j) change (%) in eGFR at measurement times A-E for (a/b) the overall NSS cohort (NSS-C), (c/d) the NSS group with intraoperative renal ischaemia (NSS-RI) and without intraoperative renal ischaemia (NSS-NRI), (e/f) the LNSS group with intraoperative renal ischaemia (LNSS-RI), the ONSS group with intraoperative renal ischaemia (ONSS-RI), (g/h) the NSS group with postoperative AKI (NSS-AKI), the NSS group without postoperative AKI (NSS-NAKI), and (i/j) NSS group with a baseline eGFR category G1 (NSS-G1), NSS group with a baseline eGFR category G2 (NSS-G2), and NSS group with a baseline eGFR category ≥G3 (NSS ≥ G3). Definition of measurement times a-e: (a) highest change in eGFR from baseline during the planned hospital stay at a median of 1 day postoperatively (IQR, 1–2), (b) change in eGFR from baseline prior to discharge from hospital at a median of 4 days postoperatively (IQR, 2–6), (c) change in eGFR from baseline at a median of 47 days postoperatively (IQR, 30–105), (d) a median of 13 months postoperatively (IQR, 12–15), and (e) a median of 50 months postoperatively (IQR, 35–81). Asterisks indicate significant changes from baseline in the level of absolute and relative changes in eGFR over the course of the observation period (Friedman’s test as a post hoc pairwise multiple comparison test) or between the compared groups at each measurement time (non-parametric Mann-Whitney U test). * p < 0.05, ** p < 0.01, *** p < 0.001, (ns) not significant. eGFR, estimated glomerular filtration rate; NSS, nephron-sparing surgery; LNSS, laparoscopic nephron-sparing surgery; ONSS, open nephronsparing surgery; AKI, acute kidney injury; IQR, interquartile range