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Table 3 Association of gout with Incident CKD, in pre-defined subgroup analyses by race, gender, and age

From: Gout is associated with a higher risk of chronic renal disease in older adults: a retrospective cohort study of U.S. Medicare population

 

Multivariable-adjusted (Model 1)

Multivariable-adjusted (Model 1)

Multivariable-adjusted (Model 1)

HR (95% CI)

P-value

HR (95% CI)

P-value

HR (95% CI)

P-value

 

Black

White

Other race

Gout

3.06 (2.93, 3.21)

< 0.0001

3.04 (2.98, 3.10)

< 0.0001

3.13 (2.91, 3.37)

< 0.0001

 

Female

Male

  

Gout

3.18 (3.09, 3.26)

< 0.0001

2.96 (2.90, 3.03)

< 0.0001

  
 

65–75 years

75–85 years

> 85 years

Gout

3.34 (3.26, 3.43)

< 0.0001

2.87 (2.80, 2.95)

< 0.0001

2.66 (2.54, 2.80)

< 0.0001

 

No Hypertension

 

Hypertension

   

Gout

4.29 (4.15, 4.44)

< 0.0001

2.38 (2.33, 2.43)

< 0.0001

  
 

No Diabetes

 

Diabetes

   

Gout

3.47 (3.40, 3.54)

< 0.0001

2.24 (2.18, 2.30)

< 0.0001

  
 

No CAD

 

CAD

   

Gout

3.32 (3.25, 3.39)

< 0.0001

2.38 (2.31, 2.46)

< 0.0001

  
  1. P-value for interactions were as follows
  2.  Race*gout interaction term, p-value 0.004
  3.  Sex*gout interaction term, p-value < 0.0001
  4.  Age*gout interaction term, p-value < 0.0001
  5.  Hypertension*gout interaction term, p-value < 0.0001
  6.  Diabetes*gout interaction term, p-value < 0.0001
  7.  CAD*gout interaction term, p-value < 0.0001
  8. HR Hazard ratio, CI confidence interval
  9. Hazard ratios that are significant with p-value < 0.05 are in bold