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Table 1 Baseline clinical characteristics and pathological features

From: Hyperuricemia and its related histopathological features on renal biopsy

 

Total

IgAN

non-IgAN

p-value

n = 1070

n = 429

n = 641

Age (years)

38 ± 15

34 ± 12

40 ± 16

<0.001

Male (n, %)

516 (48.2%)

171 (39.9%)

345 (53.8%)

<0.001

Cr (μmol/L)

84.2 ± 50.1

90.3 ± 50.8

80.1 ± 50.4

0.004

eGFR (ml/min/1.73m2)

98.1 ± 31.3

93.0 ± 32.9

101.6 ± 29.8

<0.001

Urea (mmol/L)

6.5 ± 3.7

6.8 ± 3.7

6.3 ± 3.7

0.03

Alb (g/L)

33.2 ± 9.5

38.0 ± 6.7

30.0 ± 9.7

<0.001

UA (μmol/L)

372.7 ± 104.1

382.4 ± 105.2

366.2 ± 102.8

0.01

HUA (n,%)

415 (38.8%)

188 (43.8%)

277 (35.4%)

0.84

24 h-u-pro (g/d)

1.6 (0.5,4.0)

1.2 (0.5,2.3)

2.2 (0.5,5.1)

<0.001

SBP

126.74 ± 17.87

126.13 ± 17.52

127.13 ± 18.09

0.40

DBP

78.01 ± 12.32

77.72 ± 17.16

78.19 ± 12.43

0.57

hypertension(n,%)

230 (21.5%)

85 (19.8%)

145 (22.6%)

0.60

Histopathological changes

 S0 (n,%)

812 (75.9%)

237 (55.2%)

575 (89.7%)

<0.001

 S1 (n,%)

258 (24.1%)

192 (44.8%)

66 (10.3%)

 T1 (n,%)

989 (92.4%)

369 (86.0%)

620 (96.7%)

<0.001

 T2 (n,%)

68 (6.4%)

51 (11.9%)

17 (2.7%)

 

 T3 (n,%)

13 (1.2%)

9 (2.1%)

4 (0.6%)

 
  1. Notes: Cr creatinine, eGFR estimated glomerular filtration rate, Alb albumin, UA uric acid, HUA hyperuricemia, 24 h-u-pro 24 h protein quantitation, SBP systolic blood pressure, DBP diastolic blood pressure, S0: non-segmental glomerular sclerosis, S1: segmental glomerular sclerosis, T1: mild tubular atrophy/interstitial fibrosis, T2: moderate tubular atrophy/interstitial fibrosis, T3: severe tubular atrophy/interstitial fibrosis