Table 1 Baseline characteristics at index date

Age, years^a

72.7 (68.6, 78.1)

73.1 (69, 78.5)

73.4 (68.9, 78.8)

Female

45

53

55

Hypertension

73

71

70

Diabetes

27

29

27

 Rosuvastatin

≥10 mg: 44

< 10 mg: 19

0

 Atorvastatin

≥20 mg: 55

< 20 mg: 62

0

 Simvastatin

≥80 mg: 0.3

20–40 mg: 20

< 20 mg: 40

 Lovastatin

0

40 mg: 0.2

< 40 mg: 4

 Pravastatin

0

0

≤40 mg: 52

 Fluvastatin

0

80 mg: 0.1

≤40 mg: 4

 Alcohol misuse

2

2

2

 Asthma

4

3

3

 Atrial fibrillation

12

10

10

 Cancer, lymphoma

1

1

1

 Cancer, metastatic

1

1

1

 Cancer, non-metastatic

7

6

6

 Chronic heart failure

14

11

12

 Chronic kidney disease

43

39

34

 Chronic pain

17

18

18

 Chronic pulmonary disease

21

19

18

 Chronic viral hepatitis B

0.02

0.04

0.05

 Cirrhosis

0.2

0.2

0.3

 Dementia

4

3

3

 Depression

9

9

9

 Epilepsy

1

1

1

 Hypothyroidism

14

14

14

 Inflammatory bowel disease

1

1

1

 Irritable bowel syndrome

2

2

2

 Multiple sclerosis

0.4

0.4

0.4

 Myocardial infarction

17

8

7

 Parkinson’s disease

1

1

2

 Peptic ulcer disease

1

1

1

 Peripheral vascular disease

3

3

2

 Psoriasis

1

1

1

 Rheumatoid Arthritis

4

4

3

 Schizophrenia

1

1

1

 Severe constipation

2

2

2

 Stroke or TIA

18

17

16

 Not measured

42

41

51

 Normal

46

47

39

 Moderately increased

10

10

8

 Severely increased

2

2

2

 ACEI/ARB

65

58

56

 Loop diuretics

13

11

11

 Not measured

25

27

37

  < 15

0.2

0.2

0.3

 15–29

2

2

2

 30–44

6

6

6

 45–59

15

15

13

 60–89

45

44

37

  ≥ 90

7

6

5