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Table 4 Propensity score matching analysis between the PKD and the non-PKD

From: Urinary angiotensinogen level is associated with potassium homeostasis and clinical outcome in patients with polycystic kidney disease: a prospective cohort study

Variables

Before PSM

After PSM

Non-PKD

(N = 1495)

PKD

(N = 293)

p-value

Non-PKD

(N = 196)

PKD

(N = 196)

p-value

Matched variables

 Age (years)

55.3 ± 12.0

47.0 ± 10.9

< 0.001

49.6 ± 12.9

49.1 ± 11.1

0.66

 Female (n, %)

542 (36.3)

148 (50.5)

< 0.001

87 (44.4)

87 (44.4)

> 0.999

 Charlson comorbidity index

1.6 ± 1.3

1.4 ± 1.2

0.125

1.6 ± 1.3

1.4 ± 1.2

0.098

 DM (n, %)

616 (41.2)

12 (4.1)

< 0.001

22 (11.2)

11 (5.6)

0.068

 BMI (kg/m2)

24.9 ± 3.4

23.6 ± 3.1

< 0.001

24.2 ± 3.7

24.1 ± 3.2

0.891

 eGFR (mL/min/1. 73m2)

46.6 ± 27.6

68.1 ± 34.2

< 0.001

57.7 ± 29.7

59.1 ± 30.1

0.589

 Total CO2 (mmol/L)

25.6 ± 3.7

26.6 ± 3.2

< 0.001

26.4 ± 3.2

26.3 ± 3.2

0.924

 Serum albumin (g/dL)

4.1 ± 0.4

4.4 ± 0.3

< 0.001

4.3 ± 0.3

4.4 ± 0.3

0.39

 UPCR (g/g)a

0.6 (0.2–1.9)

0.1 (0.0–0.2)

< 0.001

0.1 (0.0–0.4)

0.1 (0.0–0.3)

0.099

 Urine osmolality (mOsm/kg)a

510.4 ± 142.5

516.7 ± 156.2

0.499

513.3 ± 148.0

514.2 ± 160.8

0.845

 Diuretics (n, %)

545 (36.5)

32 (10.9)

< 0.001

29 (14.8)

26 (13.3)

0.663

Matching results

 Sodium (mmol/L)

140.9 ± 2.4

141.1 ± 2.2

0.206

140.9 ± 2.2

141.5 ± 2.0

0.007

 Chloride (mmol/L)

105.6 ± 3.7

105.6 ± 3.0

0.716

105.1 ± 3.4

106.1 ± 3.0

0.002

 Potassium (mmol/L)

4.7 ± 0.6

4.4 ± 0.4

< 0.001

4.6 ± 0.5

4.4 ± 0.5

0.004

 TTKG

6.2 ± 2.3

7.2 ± 2.8

< 0.001

6.5 ± 2.6

7.1 ± 2.4

0.021

 Urine AGT/Cr ratio (μg/g)a

33.6 (8.6–157.4)

30.5 (12.5–82.7)

0.627

17.7 (8.2–63.1)

30.5 (13.0–109.5)

0.011

 RAAS blockade (n, %)

1310 (87.7)

229 (78.2)

< 0.001

167 (85.2)

162 (82.7)

0.492

  1. aData are expressed as median and interquartile range. Comparison was done by Mann-Whitney U test before matching, and Wilcoxon signed-rank test after matching
  2. Abbreviations: PKD, polycystic kidney disease; PSM, propensity score matching; DM, diabetes mellitus; BMI, body mass index; eGFR, estimated glomerular filtration rate; CO2, carbon dioxide; UPCR, urine protein-to-creatinine ratio; TTKG, transtubular potassium gradient; AGT/Cr, angiotensinogen/creatinine