Table 3 Treatment effect of more frequent hemodialysis on left ventricular mass (LVM), the Physical Health Component Score as per SF-36 and the circulating plasma vitamin C levels in the study population
Variable | Trial | Trt | Observeld Data (Mean ± SD) | Adjusted Means and Treatment Effects (± SE or with 95% Confidence Intervals) P-value | |||||
|---|---|---|---|---|---|---|---|---|---|
Baseline | F4 | F12 | Month 4 | Month 12 | |||||
. | . | . | . | . | . | Change from Baseline | Treatment Comparison (6× vs. 3×) | Change from Baseline | Treatment Comparison (6× vs. 3×) |
LVM (g) | Daily | 3× | 179 ± 66 | . | 162 ± 75 | – | – | −13.8 ± 9.3 | −14.6 (−37.9, 8.7) P = 0.21 |
6× | 155 ± 63 | . | 135 ± 40 | – |  | −28.4 ± 8.2 | |||
PHC (SF36) | Daily | 3× | 38.9 ± 9.9 | 37.3 ± 9.1 | 38.2 ± 10.3 | −.2.4 ± 1.5 | + 4.3* (0.5, 8.1) P = 0.027 | −1.4 ± 1.8 | + 4.0 (− 0.7, 8.6) P = 0.093 |
6× | 41.8 ± 12.0 | 42.8 ± 11.1 | 43.6 ± 9.5 | +1.9 ± 1.3 | + 2.6 ± 1.7 | ||||
Plasma Vitamin C Concentration (μmol/L) | Daily | 3× | 32.6 ± 39.4 | 49.4 ± 69.2 | 25.8 ± 21.7 | 20.8 ± 12.1 | −26.2 (−57.5, 5.1) P = 0.10 | −4.8 ± 6.2 | −2.5 (− 15.6, 10.6) P = 0.70 |
6× | 25.8 ± 25.9 | 22.6 ± 17.5 | 22.4 ± 19.1 | 5.4 ± 11.0 | −7.3 ± 5.7 | ||||