Meprin β metalloproteases associated with differential metabolite profiles in the plasma and urine of mice with type 1 diabetes and diabetic nephropathy

Table 2 PCA/multivariate Analysis models for urine

	Model	# of Compounds	Total # Samples	# of Components	R2X	R2Y	Q2	# Samples in STZ	# Samples in NaC
Positive	PCA All Samples	3513	54	5	0.781		0.663
	PCA 4 wks	3513	24	2	0.711		0.627
	PCA WT STZ v WT NaC 4 wk	3513	13	2	0.783		0.676
	OPLSDA WT STZ v WT NaC 4 wk	3513	13	1 + 1	0.775	0.993	0.981	9	4
	PCA βKO STZ v βKO NaC 4wk	3513	11	2	0.770		0.634
	OPLSDA βKO STZ v βKO NaC 4wk	3513	11	1 + 0	0.598	0.596	0.444	8	3
	PCA 8 wks	3513	24	4	0.803		0.641
	PCA WT STZ v WT NaC 8 wk	3513	13	2	0.774		0.648
	OPLSDA WT STZ v WT NaC 8 wk	3513	13	1 + 1	0.642	0.937	0.916	8	5
	PCA βKO STZ v βKO NaC 8wk	3513	11	3	0.839		0.546
	OPLSDA βKO STZ v βKO NaC 8wk	3513	11	1 + 4	0.893	0.999	0.841	6	5
Negative	PCA All Samples	4116	53	8	0.753		0.486
	PCA 4 wks	4116	24	4	0.692		0.477
	PCA WT STZ v WT NaC 4 wk	4116	13	2	0.632		0.453
	OPLSDA WT STZ v WT NaC 4 wk	4116	13	1 + 3	0.73	1	0.983	9	4
	PCA βKO STZ v βKO NaC 4wk	4116	11	2	0.566		0.254
	OPLSDA βKO STZ v βKO NaC 4wk	4116	11	1 + 0	0.333	0.644	0.451	8	3
	PCA 8 wk	4116	24	4	0.646		0.327
	PCA WT STZ v WT NaC 8 wk	4116	13	4	0.767		0.311
	OPLSDA WT STZ v WT NaC 8 wk	4116	13	1 + 0	0.409	0.953	0.921	8	5
	PCA βKO STZ v βKO NaC 8wk	4116	11	2	0.574		0.174
	OPLSDA βKO STZ v βKO NaC 8wk	4116	11	1 + 6	0.894	1	0.816	6	5

ISSN: 1471-2369